TY - JOUR
T1 - C-Kit receptor and tryptase expressing mast cells correlate with angiogenesis in breast cancer patients
AU - Marech, Ilaria
AU - Ammendola, Michele
AU - Leporini, Christian
AU - Patruno, Rosa
AU - Luposella, Maria
AU - Zizzo, Nicola
AU - Passantino, Giuseppe
AU - Sacco, Rosario
AU - Farooqi, Ammad Ahmad
AU - Zuccalà, Valeria
AU - Leo, Silvana
AU - Dentamaro, Rosalba
AU - Porcelli, Mariangela
AU - Gadaleta, Pietro
AU - De Sarro, Giovambattista
AU - Gadaleta, Cosmo Damiano
AU - Ranieri, Girolamo
PY - 2018/1/1
Y1 - 2018/1/1
N2 - C-Kit protein is a transmembrane tyrosine kinase (TK) receptor (c-KitR-TK), which is predominantly expressed on mast cells (MCs) playing a role in tumor angiogenesis. It could be also expressed on epithelial breast cancer cells (EBCCs), but no data have been published regarding the correlation between mast cells positive to c-KitR (MCs-c- KitR), EBCCs positive to c-KitR (EBCCs-c-KitR), BC angiogenesis in terms of microvessel density (MVD) and the main clinic-pathological features. This study aims to evaluate the above parameters and their correlations in a series of selected 121 female early BC patients. It has been found a strong correlation between MVD and MCDPT, and MCs-c- KitR, MVD and MCs density positive to tryptase (MCDPT), and MCs-c-KitR and MCDPT by Pearson correlation. These data suggest an involvement of both MCDPT and MCsc- KitR in BC tumor angiogenesis. Furthermore, BC tissue expressing c-KitR could be a putative predictive factor to c-KitR-TK inhibitors. In this way, selected patients with higher MCs-c-KitR could be candidate to receive c-KitR-TK inhibitors (e.g. masitinib, sunitinib) or tryptase inhibitors (e.g. nafamostat mesilate, gabexate mesilate).
AB - C-Kit protein is a transmembrane tyrosine kinase (TK) receptor (c-KitR-TK), which is predominantly expressed on mast cells (MCs) playing a role in tumor angiogenesis. It could be also expressed on epithelial breast cancer cells (EBCCs), but no data have been published regarding the correlation between mast cells positive to c-KitR (MCs-c- KitR), EBCCs positive to c-KitR (EBCCs-c-KitR), BC angiogenesis in terms of microvessel density (MVD) and the main clinic-pathological features. This study aims to evaluate the above parameters and their correlations in a series of selected 121 female early BC patients. It has been found a strong correlation between MVD and MCDPT, and MCs-c- KitR, MVD and MCs density positive to tryptase (MCDPT), and MCs-c-KitR and MCDPT by Pearson correlation. These data suggest an involvement of both MCDPT and MCsc- KitR in BC tumor angiogenesis. Furthermore, BC tissue expressing c-KitR could be a putative predictive factor to c-KitR-TK inhibitors. In this way, selected patients with higher MCs-c-KitR could be candidate to receive c-KitR-TK inhibitors (e.g. masitinib, sunitinib) or tryptase inhibitors (e.g. nafamostat mesilate, gabexate mesilate).
KW - Angiogenesis
KW - Breast cancer
KW - C-Kit receptor
KW - Mast cells
KW - Tryptase
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U2 - 10.18632/oncotarget.23722
DO - 10.18632/oncotarget.23722
M3 - Article
AN - SCOPUS:85041224476
VL - 9
SP - 7918
EP - 7927
JO - Oncotarget
JF - Oncotarget
SN - 1949-2553
IS - 8
ER -