C-Kit receptor and tryptase expressing mast cells correlate with angiogenesis in breast cancer patients

Ilaria Marech, Michele Ammendola, Christian Leporini, Rosa Patruno, Maria Luposella, Nicola Zizzo, Giuseppe Passantino, Rosario Sacco, Ammad Ahmad Farooqi, Valeria Zuccalà, Silvana Leo, Rosalba Dentamaro, Mariangela Porcelli, Pietro Gadaleta, Giovambattista De Sarro, Cosmo Damiano Gadaleta, Girolamo Ranieri

Research output: Contribution to journalArticle

Abstract

C-Kit protein is a transmembrane tyrosine kinase (TK) receptor (c-KitR-TK), which is predominantly expressed on mast cells (MCs) playing a role in tumor angiogenesis. It could be also expressed on epithelial breast cancer cells (EBCCs), but no data have been published regarding the correlation between mast cells positive to c-KitR (MCs-c- KitR), EBCCs positive to c-KitR (EBCCs-c-KitR), BC angiogenesis in terms of microvessel density (MVD) and the main clinic-pathological features. This study aims to evaluate the above parameters and their correlations in a series of selected 121 female early BC patients. It has been found a strong correlation between MVD and MCDPT, and MCs-c- KitR, MVD and MCs density positive to tryptase (MCDPT), and MCs-c-KitR and MCDPT by Pearson correlation. These data suggest an involvement of both MCDPT and MCsc- KitR in BC tumor angiogenesis. Furthermore, BC tissue expressing c-KitR could be a putative predictive factor to c-KitR-TK inhibitors. In this way, selected patients with higher MCs-c-KitR could be candidate to receive c-KitR-TK inhibitors (e.g. masitinib, sunitinib) or tryptase inhibitors (e.g. nafamostat mesilate, gabexate mesilate).

Original languageEnglish
Pages (from-to)7918-7927
Number of pages10
JournalOncotarget
Volume9
Issue number8
DOIs
Publication statusPublished - Jan 1 2018

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Keywords

  • Angiogenesis
  • Breast cancer
  • C-Kit receptor
  • Mast cells
  • Tryptase

ASJC Scopus subject areas

  • Oncology

Cite this

Marech, I., Ammendola, M., Leporini, C., Patruno, R., Luposella, M., Zizzo, N., Passantino, G., Sacco, R., Farooqi, A. A., Zuccalà, V., Leo, S., Dentamaro, R., Porcelli, M., Gadaleta, P., De Sarro, G., Gadaleta, C. D., & Ranieri, G. (2018). C-Kit receptor and tryptase expressing mast cells correlate with angiogenesis in breast cancer patients. Oncotarget, 9(8), 7918-7927. https://doi.org/10.18632/oncotarget.23722