C-kit+ cells

The tell-tale heart of cardiac regeneration?

Patrizia Nigro, Gianluca Lorenzo Perrucci, Aoife Gowran, Marco Zanobini, Maurizio C. Capogrossi, Giulio Pompilio

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Cardiovascular disease is the leading cause of morbidity and mortality in the developed world. Although ongoing therapeutic strategies ameliorate symptoms and prolong life for patients with cardiovascular diseases, they do not solve the critical issue related to the loss of cardiac tissue. Accordingly, stem/progenitor cell therapy has emerged as a paramount approach for cardiac repair and regeneration. In this regard, c-kit+ cells have animated much interest and controversy. These cells are self-renewing, clonogenic, and multipotent and display a noteworthy potential to differentiate into all cardiovascular lineages. However, their functional contribution to cardiomyocyte turnover is one of the centrally debated issues concerning their regenerative potential. Regardless, plentiful preclinical and clinical studies have been conducted which provide evidence for the capacity of c-kit+ cells to improve cardiac function. The purpose of this review is to give a comprehensive, impartial, critical description and evaluation of the literature on c-kit+ cells from bench to bedside in order to address their true potential, benefits and controversies.

Original languageEnglish
Pages (from-to)1725-1740
Number of pages16
JournalCellular and Molecular Life Sciences
Volume72
Issue number9
DOIs
Publication statusPublished - May 1 2015

Fingerprint

Regeneration
Cardiovascular Diseases
Stem Cells
Cell- and Tissue-Based Therapy
Cardiac Myocytes
Morbidity
Mortality
Therapeutics

Keywords

  • c-kit<sup>+</sup> cells
  • Cardiovascular disease
  • Cell therapy
  • Myocardial regeneration

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

C-kit+ cells : The tell-tale heart of cardiac regeneration? / Nigro, Patrizia; Perrucci, Gianluca Lorenzo; Gowran, Aoife; Zanobini, Marco; Capogrossi, Maurizio C.; Pompilio, Giulio.

In: Cellular and Molecular Life Sciences, Vol. 72, No. 9, 01.05.2015, p. 1725-1740.

Research output: Contribution to journalArticle

Nigro, Patrizia ; Perrucci, Gianluca Lorenzo ; Gowran, Aoife ; Zanobini, Marco ; Capogrossi, Maurizio C. ; Pompilio, Giulio. / C-kit+ cells : The tell-tale heart of cardiac regeneration?. In: Cellular and Molecular Life Sciences. 2015 ; Vol. 72, No. 9. pp. 1725-1740.
@article{13e40b83140641feb3fe46127d7d4ab8,
title = "C-kit+ cells: The tell-tale heart of cardiac regeneration?",
abstract = "Cardiovascular disease is the leading cause of morbidity and mortality in the developed world. Although ongoing therapeutic strategies ameliorate symptoms and prolong life for patients with cardiovascular diseases, they do not solve the critical issue related to the loss of cardiac tissue. Accordingly, stem/progenitor cell therapy has emerged as a paramount approach for cardiac repair and regeneration. In this regard, c-kit+ cells have animated much interest and controversy. These cells are self-renewing, clonogenic, and multipotent and display a noteworthy potential to differentiate into all cardiovascular lineages. However, their functional contribution to cardiomyocyte turnover is one of the centrally debated issues concerning their regenerative potential. Regardless, plentiful preclinical and clinical studies have been conducted which provide evidence for the capacity of c-kit+ cells to improve cardiac function. The purpose of this review is to give a comprehensive, impartial, critical description and evaluation of the literature on c-kit+ cells from bench to bedside in order to address their true potential, benefits and controversies.",
keywords = "c-kit<sup>+</sup> cells, Cardiovascular disease, Cell therapy, Myocardial regeneration",
author = "Patrizia Nigro and Perrucci, {Gianluca Lorenzo} and Aoife Gowran and Marco Zanobini and Capogrossi, {Maurizio C.} and Giulio Pompilio",
year = "2015",
month = "5",
day = "1",
doi = "10.1007/s00018-014-1832-8",
language = "English",
volume = "72",
pages = "1725--1740",
journal = "Cellular and Molecular Life Sciences",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",
number = "9",

}

TY - JOUR

T1 - C-kit+ cells

T2 - The tell-tale heart of cardiac regeneration?

AU - Nigro, Patrizia

AU - Perrucci, Gianluca Lorenzo

AU - Gowran, Aoife

AU - Zanobini, Marco

AU - Capogrossi, Maurizio C.

AU - Pompilio, Giulio

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Cardiovascular disease is the leading cause of morbidity and mortality in the developed world. Although ongoing therapeutic strategies ameliorate symptoms and prolong life for patients with cardiovascular diseases, they do not solve the critical issue related to the loss of cardiac tissue. Accordingly, stem/progenitor cell therapy has emerged as a paramount approach for cardiac repair and regeneration. In this regard, c-kit+ cells have animated much interest and controversy. These cells are self-renewing, clonogenic, and multipotent and display a noteworthy potential to differentiate into all cardiovascular lineages. However, their functional contribution to cardiomyocyte turnover is one of the centrally debated issues concerning their regenerative potential. Regardless, plentiful preclinical and clinical studies have been conducted which provide evidence for the capacity of c-kit+ cells to improve cardiac function. The purpose of this review is to give a comprehensive, impartial, critical description and evaluation of the literature on c-kit+ cells from bench to bedside in order to address their true potential, benefits and controversies.

AB - Cardiovascular disease is the leading cause of morbidity and mortality in the developed world. Although ongoing therapeutic strategies ameliorate symptoms and prolong life for patients with cardiovascular diseases, they do not solve the critical issue related to the loss of cardiac tissue. Accordingly, stem/progenitor cell therapy has emerged as a paramount approach for cardiac repair and regeneration. In this regard, c-kit+ cells have animated much interest and controversy. These cells are self-renewing, clonogenic, and multipotent and display a noteworthy potential to differentiate into all cardiovascular lineages. However, their functional contribution to cardiomyocyte turnover is one of the centrally debated issues concerning their regenerative potential. Regardless, plentiful preclinical and clinical studies have been conducted which provide evidence for the capacity of c-kit+ cells to improve cardiac function. The purpose of this review is to give a comprehensive, impartial, critical description and evaluation of the literature on c-kit+ cells from bench to bedside in order to address their true potential, benefits and controversies.

KW - c-kit<sup>+</sup> cells

KW - Cardiovascular disease

KW - Cell therapy

KW - Myocardial regeneration

UR - http://www.scopus.com/inward/record.url?scp=84928501284&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928501284&partnerID=8YFLogxK

U2 - 10.1007/s00018-014-1832-8

DO - 10.1007/s00018-014-1832-8

M3 - Article

VL - 72

SP - 1725

EP - 1740

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

IS - 9

ER -