c-Myc activation in early coronary lesions in experimental hypercholesterolemia

F. De Nigris, L. O. Lerman, M. Rodriguez-Porcel, M. P. De Montis, A. Lerman, C. Napoli

Research output: Contribution to journalArticle

Abstract

This study tested the hypothesis that c-Myc activation, an oxidation, sensitive transcription factor, and its binding partner Max occurs in coronary arteries of hypercholesterolemic (HC) pigs, and can be attenuated by chronic antioxidant intervention. Coronary arteries were isolated from normal, HC pigs, or HC supplemented with antioxidant vitamins (HC + vitamins). The expression of the c-Myc/Max complex, and its target genes GADD45 and p53, was studied in nonatherosclerotic, early lesions (LL), positively staining for oil-red-O, in adjacent lesion-prone regions (PL), and in healthy segments (HV). The expression of c-Myc and Max in HC was 2- to 3-fold greater in PL, and 4-fold in LL, compared to normal vessels (P <0.01). The expression of GADD45 was down-regulated, and of p53 increased, in the same regions. These alterations were attenuated in the HC + vitamins. Thus, c-Myc activation is an early atherosclerosis, in both PL and LL coronary arterial regions, and can be blunted by chronic dietary antioxidant intervention.

Original languageEnglish
Pages (from-to)945-950
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume281
Issue number4
DOIs
Publication statusPublished - 2001

Keywords

  • Antioxidants
  • Atherogenesis
  • C-Myc

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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