C-myc and c-myb oncoproteins during induced maturation of myeloid and erythroid human leukemic cell lines

P. Pedrazzoli, M. A. Bains, R. Watson, J. Fisher, T. G. Hoy, A. Jacobs

Research output: Contribution to journalArticle

Abstract

c-myc and c-myb mRNAs have been found to be tightly regulated during hemopoietic differentiation. We have studied nuclear c-myc and c-myb oncoproteins through the cell cycle, during macrophage, granulocyte, erythroid, and megakaryocytic differentiation of KG1, HL60, and HEL cells. p62(c-myc) content of propidium iodide-stained nuclei was quantitated by flow cytometry using fluoresceinated antibodies CT14-G4 and MB4.3, respectively. In uninduced cells p62(c-myc) content is highest in HL60, followed by HEL, then KG1, while p75(c-myb) is highest in HEL, followed by HL60 and KG1. All lines showed a

Original languageEnglish
Pages (from-to)6911-6916
Number of pages6
JournalCancer Research
Volume49
Issue number24 I
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Pedrazzoli, P., Bains, M. A., Watson, R., Fisher, J., Hoy, T. G., & Jacobs, A. (1989). C-myc and c-myb oncoproteins during induced maturation of myeloid and erythroid human leukemic cell lines. Cancer Research, 49(24 I), 6911-6916.