C-peptide, IGF-I, sex-steroid hormones and adiposity: A cross-sectional study in healthy women within the European Prospective Investigation into Cancer and Nutrition (EPIC)

Irene D. Bezemer, Sabina Rinaldi, Laure Dossus, Carla H. Van Gils, Petra H M Peeters, Paulus A H Van Noord, H. Bas Bueno-De-Mesquita, Soren Paaske Johnsen, Kim Overvad, Anja Olsen, Anne Tjønneland, Heiner Boeing, Petra H. Lahmann, Jakob Linseisen, Gabriele Nagel, Naomi Allen, Andrew Roddam, Sheila Bingham, Kay Tee Khaw, Emmanuelle KesseBertrand Téhard, Françoise Clavel-Chapelon, Antonio Agudo, Eva Ardanaz, J. R. Quiros, Pilar Amiano, C. Martínez-Garcia, M. J. Tormo, Valeria Pala, Salvatore Panico, Paolo Vineis, Domenico Palli, Rosario Tumino, Antonia Trichopoulou, N. Baibas, D. Zilis, Bertrand Hémon, Teresa Norat, Elio Riboli, Rudolf Kaaks

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: The risk of some cancers is positively associated with body weight, which may influence circulating levels of sex-steroid hormones, insulin and IGF-I. Interrelationships between these hormones and the associations with adiposity were evaluated in healthy women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: A cross-sectional analysis was performed on anthropometric and hormonal data from 743 pre- and 1217 postmenopausal women. Body mass index (BMI) and waist circumference were used as indicators of adiposity. C-peptide, Insulin Growth Factor (IGF)-I, Insulin Growth Factor binding protein (IGFBP)-3, androgens, estrogens and sex hormone binding globulin (SHBG) were measured by immunoassays; free sex steroid concentrations were calculated. Results: BMI and waist circumference were positively correlated with estrogens in postmenopausal women and with C-peptide, free testosterone and inversely with SHBG in all women. C-peptide and IGF-I were inversely correlated with SHBG, and positively with free sex steroids in postmenopausal women. IGF-I was positively associated with postmenopausal estrogens and androgen concentrations in all women. Conclusions: Sex-steroid concentrations appear to be regulated along several axes. Adiposity correlated directly with estrogens in postmenopausal women and with insulin, resulting in lower SHBG and increased levels of free sex steroids. Independent of adiposity and insulin, IGF-I was associated with decreased SHBG levels, and increased concentrations of androgens and postmenopausal estrogens.

Original languageEnglish
Pages (from-to)561-572
Number of pages12
JournalCancer Causes and Control
Volume16
Issue number5
DOIs
Publication statusPublished - Jun 2005

Keywords

  • Anthropometry
  • IGF-I
  • Insulin
  • Sex-steroid hormones

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

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