Abstract
Background: C-reactive protein (CRP) increases during an inflammatory response; its plasma levels are believed to be an independent predictor of future atherosclerotic disease. We report the distribution of plasma levels of CRP and its possible relationship with other cardiovascular risk factors in an Italian cohort. Methods: CRP was assessed in frozen plasma samples of 1949 participants in the CHECK study (2001-2005), which collected clinical and biochemical data from randomly selected subjects (40-79 years) in the setting of Italian general practice. Results: Median CRP (interquartile range) was higher in women (1.42 [0.58-2.86] vs 1.28 [0.58-2.50]; p =.163), in people aged ≥ 65 years (1.74 [0.89-3.34] vs 1.11 [0.52-2.45]; p 2 =.264) of circulating logeCRP with body mass index, fibrinogen, apoB, age, gender, smoking habits, physical inactivity, creatinine levels, and systolic blood pressure. Conclusion: This study provides epidemiological data of CRP in the Italian population and reinforces the existing evidences about the close correlation between CRP and markers of inflammation and adiposity.
| Original language | English |
|---|---|
| Pages (from-to) | 161-166 |
| Number of pages | 6 |
| Journal | European Journal of Internal Medicine |
| Volume | 24 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 2013 |
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Keywords
- Adiposity
- C-reactive protein
- Cardiovascular risk factors
- Epidemiology
- Italian population
- Multivariate analysis
ASJC Scopus subject areas
- Internal Medicine
Cite this
C-reactive protein distribution and correlation with traditional cardiovascular risk factors in the Italian population. / Casula, Manuela; Tragni, Elena; Zambon, Antonella; Filippi, Alessandro; Brignoli, Ovidio; Cricelli, Claudio; Poli, Andrea; Catapano, Alberico L.
In: European Journal of Internal Medicine, Vol. 24, No. 2, 03.2013, p. 161-166.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - C-reactive protein distribution and correlation with traditional cardiovascular risk factors in the Italian population
AU - Casula, Manuela
AU - Tragni, Elena
AU - Zambon, Antonella
AU - Filippi, Alessandro
AU - Brignoli, Ovidio
AU - Cricelli, Claudio
AU - Poli, Andrea
AU - Catapano, Alberico L.
PY - 2013/3
Y1 - 2013/3
N2 - Background: C-reactive protein (CRP) increases during an inflammatory response; its plasma levels are believed to be an independent predictor of future atherosclerotic disease. We report the distribution of plasma levels of CRP and its possible relationship with other cardiovascular risk factors in an Italian cohort. Methods: CRP was assessed in frozen plasma samples of 1949 participants in the CHECK study (2001-2005), which collected clinical and biochemical data from randomly selected subjects (40-79 years) in the setting of Italian general practice. Results: Median CRP (interquartile range) was higher in women (1.42 [0.58-2.86] vs 1.28 [0.58-2.50]; p =.163), in people aged ≥ 65 years (1.74 [0.89-3.34] vs 1.11 [0.52-2.45]; p 2 =.264) of circulating logeCRP with body mass index, fibrinogen, apoB, age, gender, smoking habits, physical inactivity, creatinine levels, and systolic blood pressure. Conclusion: This study provides epidemiological data of CRP in the Italian population and reinforces the existing evidences about the close correlation between CRP and markers of inflammation and adiposity.
AB - Background: C-reactive protein (CRP) increases during an inflammatory response; its plasma levels are believed to be an independent predictor of future atherosclerotic disease. We report the distribution of plasma levels of CRP and its possible relationship with other cardiovascular risk factors in an Italian cohort. Methods: CRP was assessed in frozen plasma samples of 1949 participants in the CHECK study (2001-2005), which collected clinical and biochemical data from randomly selected subjects (40-79 years) in the setting of Italian general practice. Results: Median CRP (interquartile range) was higher in women (1.42 [0.58-2.86] vs 1.28 [0.58-2.50]; p =.163), in people aged ≥ 65 years (1.74 [0.89-3.34] vs 1.11 [0.52-2.45]; p 2 =.264) of circulating logeCRP with body mass index, fibrinogen, apoB, age, gender, smoking habits, physical inactivity, creatinine levels, and systolic blood pressure. Conclusion: This study provides epidemiological data of CRP in the Italian population and reinforces the existing evidences about the close correlation between CRP and markers of inflammation and adiposity.
KW - Adiposity
KW - C-reactive protein
KW - Cardiovascular risk factors
KW - Epidemiology
KW - Italian population
KW - Multivariate analysis
UR - http://www.scopus.com/inward/record.url?scp=84873722205&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873722205&partnerID=8YFLogxK
U2 - 10.1016/j.ejim.2012.09.010
DO - 10.1016/j.ejim.2012.09.010
M3 - Article
VL - 24
SP - 161
EP - 166
JO - European Journal of Internal Medicine
JF - European Journal of Internal Medicine
SN - 0953-6205
IS - 2
ER -