C-reactive protein distribution and correlation with traditional cardiovascular risk factors in the Italian population

Manuela Casula, Elena Tragni, Antonella Zambon, Alessandro Filippi, Ovidio Brignoli, Claudio Cricelli, Andrea Poli, Alberico L. Catapano

Research output: Contribution to journalArticlepeer-review

Abstract

Background: C-reactive protein (CRP) increases during an inflammatory response; its plasma levels are believed to be an independent predictor of future atherosclerotic disease. We report the distribution of plasma levels of CRP and its possible relationship with other cardiovascular risk factors in an Italian cohort. Methods: CRP was assessed in frozen plasma samples of 1949 participants in the CHECK study (2001-2005), which collected clinical and biochemical data from randomly selected subjects (40-79 years) in the setting of Italian general practice. Results: Median CRP (interquartile range) was higher in women (1.42 [0.58-2.86] vs 1.28 [0.58-2.50]; p =.163), in people aged ≥ 65 years (1.74 [0.89-3.34] vs 1.11 [0.52-2.45]; p 2 =.264) of circulating logeCRP with body mass index, fibrinogen, apoB, age, gender, smoking habits, physical inactivity, creatinine levels, and systolic blood pressure. Conclusion: This study provides epidemiological data of CRP in the Italian population and reinforces the existing evidences about the close correlation between CRP and markers of inflammation and adiposity.

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalEuropean Journal of Internal Medicine
Volume24
Issue number2
DOIs
Publication statusPublished - Mar 2013

Keywords

  • Adiposity
  • C-reactive protein
  • Cardiovascular risk factors
  • Epidemiology
  • Italian population
  • Multivariate analysis

ASJC Scopus subject areas

  • Internal Medicine

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