C-reactive protein in acute otitis media

Nicola Principi, Paola Marchisio, Lucia Bigalli, Emilia Massironi

Research output: Chapter in Book/Report/Conference proceedingChapter


This study was designed to explore whether C-reactive protein (CRP) in serum is helpful in assessing the etiologic diagnosis of acute otitis media (AOM) in children. CRP was measured serially by a radial immunodiffusion method in sera from 67 children with AOM and in 67 matched controls, affected by noninfectious neurologic disorders. In the study group 43 (64%) children had a confirmed bacterial AOM and 24 (36%) showed no bacterial growth from middle ear fluid. The upper limit of CRP in controls was 15 mg/liter. Concentrations of CRP in patients with bacterial AOM ranged from 15 mg/liter. In the patients with sterile middle ear fluid CRP ranged from 15 mg/liter. CRP >15 mg/liter showed sensitivity of 72%, specificity of 33%, predictive value of a positive test of 66% and predictive value of a negative test of 40%, in detecting bacterial AOM. Measurement of CRP should not be used in the decision regarding antimicrobial therapy for AOM in children.

Original languageEnglish
Title of host publicationPediatric Infectious Disease
Number of pages3
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)


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