C-reactive protein in acute otitis media

Nicola Principi, Paola Marchisio, Lucia Bigalli, Emilia Massironi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This study was designed to explore whether C-reactive protein (CRP) in serum is helpful in assessing the etiologic diagnosis of acute otitis media (AOM) in children. CRP was measured serially by a radial immunodiffusion method in sera from 67 children with AOM and in 67 matched controls, affected by noninfectious neurologic disorders. In the study group 43 (64%) children had a confirmed bacterial AOM and 24 (36%) showed no bacterial growth from middle ear fluid. The upper limit of CRP in controls was 15 mg/liter. Concentrations of CRP in patients with bacterial AOM ranged from 15 mg/liter. In the patients with sterile middle ear fluid CRP ranged from 15 mg/liter. CRP >15 mg/liter showed sensitivity of 72%, specificity of 33%, predictive value of a positive test of 66% and predictive value of a negative test of 40%, in detecting bacterial AOM. Measurement of CRP should not be used in the decision regarding antimicrobial therapy for AOM in children.

Original languageEnglish
Title of host publicationPediatric Infectious Disease
Pages525-527
Number of pages3
Volume5
Edition5
Publication statusPublished - 1986

    Fingerprint

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

Principi, N., Marchisio, P., Bigalli, L., & Massironi, E. (1986). C-reactive protein in acute otitis media. In Pediatric Infectious Disease (5 ed., Vol. 5, pp. 525-527)