C-reactive protein in acute otitis media

Nicola Principi, Paola Marchisio, Lucia Bigalli, Emilia Massironi

Research output: Contribution to journalArticlepeer-review


This study was designed to explore whether C-reactive protein (CRP) in serum is helpful in assessing the etiologic diagnosis of acute otitis media (AOM) in children. CRP was measured serially by a radial immunodiffusion method in sera from 67 children with AOM and in 67 matched controls, affected by noninfectious neurologic disorders. In the study group 43 (64%) children had a confirmed bacterial AOM and 24 (36%) showed no bacterial growth from middle ear fluid. The upper limit of CRP in controls was 15 mg/liter. Concentrations of CRP in patients with bacterial AOM ranged from 15 mg/liter. In the patients with sterile middle ear fluid CRP ranged from 15 mg/liter. CRP >15 mg/liter showed sensitivity of 72%, specificity of 33%, predictive value of a positive test of 66% and predictive value of a negative test of 40%, in detecting bacterial AOM. Measurement of CRP should not be used in the decision regarding antimicrobial therapy for AOM in children.

Original languageEnglish
Pages (from-to)520-524
Number of pages5
JournalPediatric Infectious Disease Journal
Issue number5
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Pediatrics, Perinatology, and Child Health


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