C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging

Wanda Acampa, Maria D. Di Taranto, Alberto Morgante, Barbara Salvatore, Laura Evangelista, Francesca Ricci, Pierluigi Costanzo, Emma De Sisto, Pasquale P. Filardi, Mario Petretta, Giuliana Fortunato, Alberto Cuocolo

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Abstract

Background. Oxidation and inflammation are linked processes playing an important role in the development and progression of coronary artery disease (CAD). The relation between oxidation and inflammation markers with myocardial ischemia is still controversial. We assessed the association between paraoxonase (PON) polymorphisms (rs854560, rs662, rs7493) and high sensitivity C-reactive protein levels with stress-induced ischemia in patients with suspected CAD. Materials and methods. Patients (n = 203; 78 men; mean age 59 ± 10 years), with suspected CAD underwent on the same day stress/rest Tc-99m sestamibi cardiac single-photon emission computed tomography and venous blood samples collection, to assess PON polymorphisms, lipid profile and high sensitivity C-reactive protein levels. Results. At cardiac tomography, 43 (21%) patients had stress-induced myocardial ischemia and 160 (79%) did not. At logistic regression analysis, diabetes (p <0.005), sex (p = 0.020) and high-density lipoprotein (HDL)-cholesterol levels (p <0.050) were independently associated with stress-induced ischemia. No differences of PON1 and PON2 genotype frequencies were observed between patients with and without stress-induced ischemia. Multiple linear regression analysis showed that LL genotype for PON1 (p <0.03), high body mass index (BMI) values (p <0.001) and low HDL-cholesterol levels (p <0.05) are associated with high C-reactive protein levels independently from presence of stress-induced ischemia, age, sex, diabetes, hypertension, statin therapy, smoking and total cholesterol levels. Conclusions. The results of this study identified a weak association between the M55L polymorphism in PON1 gene and C-reactive protein levels. BMI showed a major role in the determination of C-reactive protein levels. No association between PON polymorphisms and stress-induced ischemia was found.

Original languageEnglish
Pages (from-to)179-184
Number of pages6
JournalScandinavian Journal of Clinical and Laboratory Investigation
Volume71
Issue number3
DOIs
Publication statusPublished - May 2011

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Aryldialkylphosphatase
Single-Photon Emission-Computed Tomography
Polymorphism
C-Reactive Protein
Ischemia
Imaging techniques
Coronary Artery Disease
HDL Cholesterol
Myocardial Ischemia
Body Mass Index
Genotype
Medical problems
Regression Analysis
Regression analysis
Inflammation
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Association reactions
Single photon emission computed tomography
LDL Cholesterol
Oxidation

Keywords

  • C-reactive protein
  • Inflammation
  • myocardial ischemia
  • paraoxonase
  • single nucleotide polymorphisms

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging. / Acampa, Wanda; Di Taranto, Maria D.; Morgante, Alberto; Salvatore, Barbara; Evangelista, Laura; Ricci, Francesca; Costanzo, Pierluigi; De Sisto, Emma; Filardi, Pasquale P.; Petretta, Mario; Fortunato, Giuliana; Cuocolo, Alberto.

In: Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 71, No. 3, 05.2011, p. 179-184.

Research output: Contribution to journalArticle

Acampa, W, Di Taranto, MD, Morgante, A, Salvatore, B, Evangelista, L, Ricci, F, Costanzo, P, De Sisto, E, Filardi, PP, Petretta, M, Fortunato, G & Cuocolo, A 2011, 'C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging', Scandinavian Journal of Clinical and Laboratory Investigation, vol. 71, no. 3, pp. 179-184. https://doi.org/10.3109/00365513.2010.548529
Acampa, Wanda ; Di Taranto, Maria D. ; Morgante, Alberto ; Salvatore, Barbara ; Evangelista, Laura ; Ricci, Francesca ; Costanzo, Pierluigi ; De Sisto, Emma ; Filardi, Pasquale P. ; Petretta, Mario ; Fortunato, Giuliana ; Cuocolo, Alberto. / C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging. In: Scandinavian Journal of Clinical and Laboratory Investigation. 2011 ; Vol. 71, No. 3. pp. 179-184.
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abstract = "Background. Oxidation and inflammation are linked processes playing an important role in the development and progression of coronary artery disease (CAD). The relation between oxidation and inflammation markers with myocardial ischemia is still controversial. We assessed the association between paraoxonase (PON) polymorphisms (rs854560, rs662, rs7493) and high sensitivity C-reactive protein levels with stress-induced ischemia in patients with suspected CAD. Materials and methods. Patients (n = 203; 78 men; mean age 59 ± 10 years), with suspected CAD underwent on the same day stress/rest Tc-99m sestamibi cardiac single-photon emission computed tomography and venous blood samples collection, to assess PON polymorphisms, lipid profile and high sensitivity C-reactive protein levels. Results. At cardiac tomography, 43 (21{\%}) patients had stress-induced myocardial ischemia and 160 (79{\%}) did not. At logistic regression analysis, diabetes (p <0.005), sex (p = 0.020) and high-density lipoprotein (HDL)-cholesterol levels (p <0.050) were independently associated with stress-induced ischemia. No differences of PON1 and PON2 genotype frequencies were observed between patients with and without stress-induced ischemia. Multiple linear regression analysis showed that LL genotype for PON1 (p <0.03), high body mass index (BMI) values (p <0.001) and low HDL-cholesterol levels (p <0.05) are associated with high C-reactive protein levels independently from presence of stress-induced ischemia, age, sex, diabetes, hypertension, statin therapy, smoking and total cholesterol levels. Conclusions. The results of this study identified a weak association between the M55L polymorphism in PON1 gene and C-reactive protein levels. BMI showed a major role in the determination of C-reactive protein levels. No association between PON polymorphisms and stress-induced ischemia was found.",
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T1 - C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging

AU - Acampa, Wanda

AU - Di Taranto, Maria D.

AU - Morgante, Alberto

AU - Salvatore, Barbara

AU - Evangelista, Laura

AU - Ricci, Francesca

AU - Costanzo, Pierluigi

AU - De Sisto, Emma

AU - Filardi, Pasquale P.

AU - Petretta, Mario

AU - Fortunato, Giuliana

AU - Cuocolo, Alberto

PY - 2011/5

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N2 - Background. Oxidation and inflammation are linked processes playing an important role in the development and progression of coronary artery disease (CAD). The relation between oxidation and inflammation markers with myocardial ischemia is still controversial. We assessed the association between paraoxonase (PON) polymorphisms (rs854560, rs662, rs7493) and high sensitivity C-reactive protein levels with stress-induced ischemia in patients with suspected CAD. Materials and methods. Patients (n = 203; 78 men; mean age 59 ± 10 years), with suspected CAD underwent on the same day stress/rest Tc-99m sestamibi cardiac single-photon emission computed tomography and venous blood samples collection, to assess PON polymorphisms, lipid profile and high sensitivity C-reactive protein levels. Results. At cardiac tomography, 43 (21%) patients had stress-induced myocardial ischemia and 160 (79%) did not. At logistic regression analysis, diabetes (p <0.005), sex (p = 0.020) and high-density lipoprotein (HDL)-cholesterol levels (p <0.050) were independently associated with stress-induced ischemia. No differences of PON1 and PON2 genotype frequencies were observed between patients with and without stress-induced ischemia. Multiple linear regression analysis showed that LL genotype for PON1 (p <0.03), high body mass index (BMI) values (p <0.001) and low HDL-cholesterol levels (p <0.05) are associated with high C-reactive protein levels independently from presence of stress-induced ischemia, age, sex, diabetes, hypertension, statin therapy, smoking and total cholesterol levels. Conclusions. The results of this study identified a weak association between the M55L polymorphism in PON1 gene and C-reactive protein levels. BMI showed a major role in the determination of C-reactive protein levels. No association between PON polymorphisms and stress-induced ischemia was found.

AB - Background. Oxidation and inflammation are linked processes playing an important role in the development and progression of coronary artery disease (CAD). The relation between oxidation and inflammation markers with myocardial ischemia is still controversial. We assessed the association between paraoxonase (PON) polymorphisms (rs854560, rs662, rs7493) and high sensitivity C-reactive protein levels with stress-induced ischemia in patients with suspected CAD. Materials and methods. Patients (n = 203; 78 men; mean age 59 ± 10 years), with suspected CAD underwent on the same day stress/rest Tc-99m sestamibi cardiac single-photon emission computed tomography and venous blood samples collection, to assess PON polymorphisms, lipid profile and high sensitivity C-reactive protein levels. Results. At cardiac tomography, 43 (21%) patients had stress-induced myocardial ischemia and 160 (79%) did not. At logistic regression analysis, diabetes (p <0.005), sex (p = 0.020) and high-density lipoprotein (HDL)-cholesterol levels (p <0.050) were independently associated with stress-induced ischemia. No differences of PON1 and PON2 genotype frequencies were observed between patients with and without stress-induced ischemia. Multiple linear regression analysis showed that LL genotype for PON1 (p <0.03), high body mass index (BMI) values (p <0.001) and low HDL-cholesterol levels (p <0.05) are associated with high C-reactive protein levels independently from presence of stress-induced ischemia, age, sex, diabetes, hypertension, statin therapy, smoking and total cholesterol levels. Conclusions. The results of this study identified a weak association between the M55L polymorphism in PON1 gene and C-reactive protein levels. BMI showed a major role in the determination of C-reactive protein levels. No association between PON polymorphisms and stress-induced ischemia was found.

KW - C-reactive protein

KW - Inflammation

KW - myocardial ischemia

KW - paraoxonase

KW - single nucleotide polymorphisms

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