Abstract
Background. Oxidation and inflammation are linked processes playing an important role in the development and progression of coronary artery disease (CAD). The relation between oxidation and inflammation markers with myocardial ischemia is still controversial. We assessed the association between paraoxonase (PON) polymorphisms (rs854560, rs662, rs7493) and high sensitivity C-reactive protein levels with stress-induced ischemia in patients with suspected CAD. Materials and methods. Patients (n = 203; 78 men; mean age 59 ± 10 years), with suspected CAD underwent on the same day stress/rest Tc-99m sestamibi cardiac single-photon emission computed tomography and venous blood samples collection, to assess PON polymorphisms, lipid profile and high sensitivity C-reactive protein levels. Results. At cardiac tomography, 43 (21%) patients had stress-induced myocardial ischemia and 160 (79%) did not. At logistic regression analysis, diabetes (p <0.005), sex (p = 0.020) and high-density lipoprotein (HDL)-cholesterol levels (p <0.050) were independently associated with stress-induced ischemia. No differences of PON1 and PON2 genotype frequencies were observed between patients with and without stress-induced ischemia. Multiple linear regression analysis showed that LL genotype for PON1 (p <0.03), high body mass index (BMI) values (p <0.001) and low HDL-cholesterol levels (p <0.05) are associated with high C-reactive protein levels independently from presence of stress-induced ischemia, age, sex, diabetes, hypertension, statin therapy, smoking and total cholesterol levels. Conclusions. The results of this study identified a weak association between the M55L polymorphism in PON1 gene and C-reactive protein levels. BMI showed a major role in the determination of C-reactive protein levels. No association between PON polymorphisms and stress-induced ischemia was found.
| Original language | English |
|---|---|
| Pages (from-to) | 179-184 |
| Number of pages | 6 |
| Journal | Scandinavian Journal of Clinical and Laboratory Investigation |
| Volume | 71 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 2011 |
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Keywords
- C-reactive protein
- Inflammation
- myocardial ischemia
- paraoxonase
- single nucleotide polymorphisms
ASJC Scopus subject areas
- Clinical Biochemistry
Cite this
C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging. / Acampa, Wanda; Di Taranto, Maria D.; Morgante, Alberto; Salvatore, Barbara; Evangelista, Laura; Ricci, Francesca; Costanzo, Pierluigi; De Sisto, Emma; Filardi, Pasquale P.; Petretta, Mario; Fortunato, Giuliana; Cuocolo, Alberto.
In: Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 71, No. 3, 05.2011, p. 179-184.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging
AU - Acampa, Wanda
AU - Di Taranto, Maria D.
AU - Morgante, Alberto
AU - Salvatore, Barbara
AU - Evangelista, Laura
AU - Ricci, Francesca
AU - Costanzo, Pierluigi
AU - De Sisto, Emma
AU - Filardi, Pasquale P.
AU - Petretta, Mario
AU - Fortunato, Giuliana
AU - Cuocolo, Alberto
PY - 2011/5
Y1 - 2011/5
N2 - Background. Oxidation and inflammation are linked processes playing an important role in the development and progression of coronary artery disease (CAD). The relation between oxidation and inflammation markers with myocardial ischemia is still controversial. We assessed the association between paraoxonase (PON) polymorphisms (rs854560, rs662, rs7493) and high sensitivity C-reactive protein levels with stress-induced ischemia in patients with suspected CAD. Materials and methods. Patients (n = 203; 78 men; mean age 59 ± 10 years), with suspected CAD underwent on the same day stress/rest Tc-99m sestamibi cardiac single-photon emission computed tomography and venous blood samples collection, to assess PON polymorphisms, lipid profile and high sensitivity C-reactive protein levels. Results. At cardiac tomography, 43 (21%) patients had stress-induced myocardial ischemia and 160 (79%) did not. At logistic regression analysis, diabetes (p <0.005), sex (p = 0.020) and high-density lipoprotein (HDL)-cholesterol levels (p <0.050) were independently associated with stress-induced ischemia. No differences of PON1 and PON2 genotype frequencies were observed between patients with and without stress-induced ischemia. Multiple linear regression analysis showed that LL genotype for PON1 (p <0.03), high body mass index (BMI) values (p <0.001) and low HDL-cholesterol levels (p <0.05) are associated with high C-reactive protein levels independently from presence of stress-induced ischemia, age, sex, diabetes, hypertension, statin therapy, smoking and total cholesterol levels. Conclusions. The results of this study identified a weak association between the M55L polymorphism in PON1 gene and C-reactive protein levels. BMI showed a major role in the determination of C-reactive protein levels. No association between PON polymorphisms and stress-induced ischemia was found.
AB - Background. Oxidation and inflammation are linked processes playing an important role in the development and progression of coronary artery disease (CAD). The relation between oxidation and inflammation markers with myocardial ischemia is still controversial. We assessed the association between paraoxonase (PON) polymorphisms (rs854560, rs662, rs7493) and high sensitivity C-reactive protein levels with stress-induced ischemia in patients with suspected CAD. Materials and methods. Patients (n = 203; 78 men; mean age 59 ± 10 years), with suspected CAD underwent on the same day stress/rest Tc-99m sestamibi cardiac single-photon emission computed tomography and venous blood samples collection, to assess PON polymorphisms, lipid profile and high sensitivity C-reactive protein levels. Results. At cardiac tomography, 43 (21%) patients had stress-induced myocardial ischemia and 160 (79%) did not. At logistic regression analysis, diabetes (p <0.005), sex (p = 0.020) and high-density lipoprotein (HDL)-cholesterol levels (p <0.050) were independently associated with stress-induced ischemia. No differences of PON1 and PON2 genotype frequencies were observed between patients with and without stress-induced ischemia. Multiple linear regression analysis showed that LL genotype for PON1 (p <0.03), high body mass index (BMI) values (p <0.001) and low HDL-cholesterol levels (p <0.05) are associated with high C-reactive protein levels independently from presence of stress-induced ischemia, age, sex, diabetes, hypertension, statin therapy, smoking and total cholesterol levels. Conclusions. The results of this study identified a weak association between the M55L polymorphism in PON1 gene and C-reactive protein levels. BMI showed a major role in the determination of C-reactive protein levels. No association between PON polymorphisms and stress-induced ischemia was found.
KW - C-reactive protein
KW - Inflammation
KW - myocardial ischemia
KW - paraoxonase
KW - single nucleotide polymorphisms
UR - http://www.scopus.com/inward/record.url?scp=79954551624&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79954551624&partnerID=8YFLogxK
U2 - 10.3109/00365513.2010.548529
DO - 10.3109/00365513.2010.548529
M3 - Article
C2 - 21231776
AN - SCOPUS:79954551624
VL - 71
SP - 179
EP - 184
JO - Scandinavian Journal of Clinical and Laboratory Investigation
JF - Scandinavian Journal of Clinical and Laboratory Investigation
SN - 0036-5513
IS - 3
ER -