TY - JOUR
T1 - C-reactive protein levels in the first days of life
T2 - A systematic statistical approach
AU - Coghe, Ferdinando
AU - Orrù, Germano
AU - Ferraguti, Patrizia
AU - Accossu, Simonetta
AU - Faa, Renata
AU - Erriu, Matteo
AU - Coni, Pierpaolo
AU - Piras, Vincenzo
AU - Denotti, Gloria
AU - Pautasso, Marisa
AU - Mussap, Michele
AU - Fanos, Vassilios
PY - 2012/10
Y1 - 2012/10
N2 - Objective: Microbial neonatal infections are responsible for considerable morbidity and mortality and for this reason there is a growing interest for new approaches in the clinical government of this human affection. Using an integrated statistical model, this work investigated the role of the C-reactive protein (CRP) in the diagnosis of sepsis and therapy assessment in newborns admitted in neonatal intensive care unit. Methods: 386 newborns admitted in neonatal intensive care unit were enrolled in this work. Different clinical-laboratory parameters, such as: CRP level, blood culture, complete blood cell count, urine and other blood tests were assessed for the first 7 days after birth. Several statistical methods have been used to estimate the correlation CRPsepticaemia, using Chi-squared, Pearson, analysis of the variance and Poisson distribution. Results: a statistical positive correlation (CRP value vs. septicaemia status) was observed to integrate the analysis of the variance and Poisson distribution methods, especially in the first days after birth. Conclusion: A correct statistical evaluation of CRP values could be significant for risk prediction and subsequent prompt therapy in neonatal sepsis.
AB - Objective: Microbial neonatal infections are responsible for considerable morbidity and mortality and for this reason there is a growing interest for new approaches in the clinical government of this human affection. Using an integrated statistical model, this work investigated the role of the C-reactive protein (CRP) in the diagnosis of sepsis and therapy assessment in newborns admitted in neonatal intensive care unit. Methods: 386 newborns admitted in neonatal intensive care unit were enrolled in this work. Different clinical-laboratory parameters, such as: CRP level, blood culture, complete blood cell count, urine and other blood tests were assessed for the first 7 days after birth. Several statistical methods have been used to estimate the correlation CRPsepticaemia, using Chi-squared, Pearson, analysis of the variance and Poisson distribution. Results: a statistical positive correlation (CRP value vs. septicaemia status) was observed to integrate the analysis of the variance and Poisson distribution methods, especially in the first days after birth. Conclusion: A correct statistical evaluation of CRP values could be significant for risk prediction and subsequent prompt therapy in neonatal sepsis.
KW - ANOVA and Poisson distribution methods
KW - C-reactive protein
KW - Clinical government
KW - Newborn
KW - Sepsis
UR - http://www.scopus.com/inward/record.url?scp=84866994769&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866994769&partnerID=8YFLogxK
U2 - 10.3109/14767058.2012.717464
DO - 10.3109/14767058.2012.717464
M3 - Article
C2 - 23025768
AN - SCOPUS:84866994769
VL - 25
SP - 47
EP - 50
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
SN - 1476-7058
IS - SUPPL. 5
ER -