C-reactive protein levels in the first days of life: A systematic statistical approach

Ferdinando Coghe, Germano Orrù, Patrizia Ferraguti, Simonetta Accossu, Renata Faa, Matteo Erriu, Pierpaolo Coni, Vincenzo Piras, Gloria Denotti, Marisa Pautasso, Michele Mussap, Vassilios Fanos

Research output: Contribution to journalArticlepeer-review


Objective: Microbial neonatal infections are responsible for considerable morbidity and mortality and for this reason there is a growing interest for new approaches in the clinical government of this human affection. Using an integrated statistical model, this work investigated the role of the C-reactive protein (CRP) in the diagnosis of sepsis and therapy assessment in newborns admitted in neonatal intensive care unit. Methods: 386 newborns admitted in neonatal intensive care unit were enrolled in this work. Different clinical-laboratory parameters, such as: CRP level, blood culture, complete blood cell count, urine and other blood tests were assessed for the first 7 days after birth. Several statistical methods have been used to estimate the correlation CRPsepticaemia, using Chi-squared, Pearson, analysis of the variance and Poisson distribution. Results: a statistical positive correlation (CRP value vs. septicaemia status) was observed to integrate the analysis of the variance and Poisson distribution methods, especially in the first days after birth. Conclusion: A correct statistical evaluation of CRP values could be significant for risk prediction and subsequent prompt therapy in neonatal sepsis.

Original languageEnglish
Pages (from-to)47-50
Number of pages4
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue numberSUPPL. 5
Publication statusPublished - Oct 2012


  • ANOVA and Poisson distribution methods
  • C-reactive protein
  • Clinical government
  • Newborn
  • Sepsis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology


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