C3-Fullero-tris-methanodicarboxylic acid protects epithelial cells from radiation-induced anoikia by influencing cell adhesion ability

Elisabetta Straface, Benedetto Natalini, Daniela Monti, Claudio Franceschi, Gennaro Schettini, Michela Bisaglia, Cristiana Fumelli, Carlo Pincelli, Roberto Pellicciari, Walter Malorni

Research output: Contribution to journalArticlepeer-review

Abstract

Anoikia is a type of apoptotic cell death that occurs in cells that are substrate-restricted in their growth. Buckminsterfullerenes represent a new class of chemical compounds with wide potential pharmacological antioxidant activity. In this report we provide the first demonstration that a water-soluble fullerene derivative, C3-fullero-tris-methanodicarboxylic acid, synthesized in our laboratories, is capable of inducing anoikia resistance in epithelial cells by a mechanism involving a 'trophic' effect on cell spreading-associated cytoskeletal components, i.e. on actin microfilaments. Copyright (C) 1999 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)335-340
Number of pages6
JournalFEBS Letters
Volume454
Issue number3
DOIs
Publication statusPublished - Jul 9 1999

Keywords

  • Anoikia
  • Cytoskeleton
  • Epithelial cell
  • Fullerene
  • Ultraviolet B

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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