C3-Fullero-tris-methanodicarboxylic acid protects epithelial cells from radiation-induced anoikia by influencing cell adhesion ability

Elisabetta Straface; Benedetto Natalini; Daniela Monti; Claudio Franceschi; Gennaro Schettini; Michela Bisaglia; Cristiana Fumelli; Carlo Pincelli; Roberto Pellicciari; Walter Malorni

doi:10.1016/S0014-5793(99)00812-1

C3-Fullero-tris-methanodicarboxylic acid protects epithelial cells from radiation-induced anoikia by influencing cell adhesion ability

Elisabetta Straface, Benedetto Natalini, Daniela Monti, Claudio Franceschi, Gennaro Schettini, Michela Bisaglia, Cristiana Fumelli, Carlo Pincelli, Roberto Pellicciari, Walter Malorni

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

Anoikia is a type of apoptotic cell death that occurs in cells that are substrate-restricted in their growth. Buckminsterfullerenes represent a new class of chemical compounds with wide potential pharmacological antioxidant activity. In this report we provide the first demonstration that a water-soluble fullerene derivative, C₃-fullero-tris-methanodicarboxylic acid, synthesized in our laboratories, is capable of inducing anoikia resistance in epithelial cells by a mechanism involving a 'trophic' effect on cell spreading-associated cytoskeletal components, i.e. on actin microfilaments. Copyright (C) 1999 Federation of European Biochemical Societies.

Original language	English
Pages (from-to)	335-340
Number of pages	6
Journal	FEBS Letters
Volume	454
Issue number	3
DOIs	https://doi.org/10.1016/S0014-5793(99)00812-1
Publication status	Published - Jul 9 1999

Keywords

Anoikia
Cytoskeleton
Epithelial cell
Fullerene
Ultraviolet B

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

Access to Document

10.1016/S0014-5793(99)00812-1

Cite this

C3-Fullero-tris-methanodicarboxylic acid protects epithelial cells from radiation-induced anoikia by influencing cell adhesion ability. / Straface, Elisabetta; Natalini, Benedetto; Monti, Daniela; Franceschi, Claudio; Schettini, Gennaro; Bisaglia, Michela; Fumelli, Cristiana; Pincelli, Carlo; Pellicciari, Roberto; Malorni, Walter.

In: FEBS Letters, Vol. 454, No. 3, 09.07.1999, p. 335-340.

Research output: Contribution to journal › Article › peer-review

Straface, Elisabetta ; Natalini, Benedetto ; Monti, Daniela ; Franceschi, Claudio ; Schettini, Gennaro ; Bisaglia, Michela ; Fumelli, Cristiana ; Pincelli, Carlo ; Pellicciari, Roberto ; Malorni, Walter. / C3-Fullero-tris-methanodicarboxylic acid protects epithelial cells from radiation-induced anoikia by influencing cell adhesion ability. In: FEBS Letters. 1999 ; Vol. 454, No. 3. pp. 335-340.

@article{7e26bef726384ca9970cdf8e088c3f32,

title = "C3-Fullero-tris-methanodicarboxylic acid protects epithelial cells from radiation-induced anoikia by influencing cell adhesion ability",

abstract = "Anoikia is a type of apoptotic cell death that occurs in cells that are substrate-restricted in their growth. Buckminsterfullerenes represent a new class of chemical compounds with wide potential pharmacological antioxidant activity. In this report we provide the first demonstration that a water-soluble fullerene derivative, C3-fullero-tris-methanodicarboxylic acid, synthesized in our laboratories, is capable of inducing anoikia resistance in epithelial cells by a mechanism involving a 'trophic' effect on cell spreading-associated cytoskeletal components, i.e. on actin microfilaments. Copyright (C) 1999 Federation of European Biochemical Societies.",

keywords = "Anoikia, Cytoskeleton, Epithelial cell, Fullerene, Ultraviolet B",

author = "Elisabetta Straface and Benedetto Natalini and Daniela Monti and Claudio Franceschi and Gennaro Schettini and Michela Bisaglia and Cristiana Fumelli and Carlo Pincelli and Roberto Pellicciari and Walter Malorni",

year = "1999",

month = jul,

day = "9",

doi = "10.1016/S0014-5793(99)00812-1",

language = "English",

volume = "454",

pages = "335--340",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - C3-Fullero-tris-methanodicarboxylic acid protects epithelial cells from radiation-induced anoikia by influencing cell adhesion ability

AU - Straface, Elisabetta

AU - Natalini, Benedetto

AU - Monti, Daniela

AU - Franceschi, Claudio

AU - Schettini, Gennaro

AU - Bisaglia, Michela

AU - Fumelli, Cristiana

AU - Pincelli, Carlo

AU - Pellicciari, Roberto

AU - Malorni, Walter

PY - 1999/7/9

Y1 - 1999/7/9

N2 - Anoikia is a type of apoptotic cell death that occurs in cells that are substrate-restricted in their growth. Buckminsterfullerenes represent a new class of chemical compounds with wide potential pharmacological antioxidant activity. In this report we provide the first demonstration that a water-soluble fullerene derivative, C3-fullero-tris-methanodicarboxylic acid, synthesized in our laboratories, is capable of inducing anoikia resistance in epithelial cells by a mechanism involving a 'trophic' effect on cell spreading-associated cytoskeletal components, i.e. on actin microfilaments. Copyright (C) 1999 Federation of European Biochemical Societies.

AB - Anoikia is a type of apoptotic cell death that occurs in cells that are substrate-restricted in their growth. Buckminsterfullerenes represent a new class of chemical compounds with wide potential pharmacological antioxidant activity. In this report we provide the first demonstration that a water-soluble fullerene derivative, C3-fullero-tris-methanodicarboxylic acid, synthesized in our laboratories, is capable of inducing anoikia resistance in epithelial cells by a mechanism involving a 'trophic' effect on cell spreading-associated cytoskeletal components, i.e. on actin microfilaments. Copyright (C) 1999 Federation of European Biochemical Societies.

KW - Anoikia

KW - Cytoskeleton

KW - Epithelial cell

KW - Fullerene

KW - Ultraviolet B

UR - http://www.scopus.com/inward/record.url?scp=0032587166&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032587166&partnerID=8YFLogxK

U2 - 10.1016/S0014-5793(99)00812-1

DO - 10.1016/S0014-5793(99)00812-1

M3 - Article

C2 - 10431834

AN - SCOPUS:0032587166

VL - 454

SP - 335

EP - 340

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 3

ER -

C3-Fullero-tris-methanodicarboxylic acid protects epithelial cells from radiation-induced anoikia by influencing cell adhesion ability

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this