TY - JOUR
T1 - C3-Fullero-tris-methanodicarboxylic acid protects epithelial cells from radiation-induced anoikia by influencing cell adhesion ability
AU - Straface, Elisabetta
AU - Natalini, Benedetto
AU - Monti, Daniela
AU - Franceschi, Claudio
AU - Schettini, Gennaro
AU - Bisaglia, Michela
AU - Fumelli, Cristiana
AU - Pincelli, Carlo
AU - Pellicciari, Roberto
AU - Malorni, Walter
PY - 1999/7/9
Y1 - 1999/7/9
N2 - Anoikia is a type of apoptotic cell death that occurs in cells that are substrate-restricted in their growth. Buckminsterfullerenes represent a new class of chemical compounds with wide potential pharmacological antioxidant activity. In this report we provide the first demonstration that a water-soluble fullerene derivative, C3-fullero-tris-methanodicarboxylic acid, synthesized in our laboratories, is capable of inducing anoikia resistance in epithelial cells by a mechanism involving a 'trophic' effect on cell spreading-associated cytoskeletal components, i.e. on actin microfilaments. Copyright (C) 1999 Federation of European Biochemical Societies.
AB - Anoikia is a type of apoptotic cell death that occurs in cells that are substrate-restricted in their growth. Buckminsterfullerenes represent a new class of chemical compounds with wide potential pharmacological antioxidant activity. In this report we provide the first demonstration that a water-soluble fullerene derivative, C3-fullero-tris-methanodicarboxylic acid, synthesized in our laboratories, is capable of inducing anoikia resistance in epithelial cells by a mechanism involving a 'trophic' effect on cell spreading-associated cytoskeletal components, i.e. on actin microfilaments. Copyright (C) 1999 Federation of European Biochemical Societies.
KW - Anoikia
KW - Cytoskeleton
KW - Epithelial cell
KW - Fullerene
KW - Ultraviolet B
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U2 - 10.1016/S0014-5793(99)00812-1
DO - 10.1016/S0014-5793(99)00812-1
M3 - Article
C2 - 10431834
AN - SCOPUS:0032587166
VL - 454
SP - 335
EP - 340
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 3
ER -