C3-glomerulopathy and MGUS: the skin beyond the kidney

GA Ramirez, G De Luca, G Dell'Antonio, E Baldissera, GV Suma, M Tresoldi, L Dagna

Research output: Contribution to journalArticle

Abstract

C3-glomerulopathy (C3G) is a rare disease characterised by the deposition of C3 within the glomeruli. Monoclonal gammopathy of undetermined significance (MGUS) may associate with C3G and affect its clinical course and prognosis. The association between paraproteinemia and C3G is stronger in a subset of older patients with guarded prognosis and provides a pathogenic link between C3G and other MGUS-related renal diseases, collectively referred to as monoclonal gammopathies of renal significance. Here, we describe a unique case with additional cutaneous and vascular significance, characterised by widespread C3 deposition at sites of inflammation. © The Author 2017. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
Original languageEnglish
Pages (from-to)187-188
Number of pages2
JournalQJM - Monthly Journal of the Association of Physicians
Volume111
Issue number3
DOIs
Publication statusPublished - 2018

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