Abstract
Background and methods. Host may have a role in the evolution of chronic HCV liver disease. We performed two cross-sectional prospective studies to evaluate the prevalence of cirrhosis in first degree relatives of patients with cirrhosis and the role of two major histocompatibility complex class III alleles BF and C4 versus HCV as risk factors for familial clustering. Findings. Ninety-three (18.6%) of 500 patients with cirrhosis had at least one cirrhotic first degree relative as compared to 13 (2.6%) of 500 controls, (OR 7.38; CI 4.21-12.9). C4BQO was significantly more frequent in the 93 cirrhotic patients than in 93 cirrhotic controls without familiarity (Hardy-Weinberg equilibrium: χ2 5.76, P = 0.016) and in 20 families with versus 20 without aggregation of HCV related cirrhosis (29.2% versus 11.3%, P = 0.001); the association C4BQO-HCV was found almost only in cirrhotic patients with a family history of liver cirrhosis. Conclusions. Our studies support the value of C4BQO as a risk indicator of familial HCV related cirrhosis.
| Original language | English |
|---|---|
| Pages (from-to) | 471-477 |
| Number of pages | 7 |
| Journal | Digestive and Liver Disease |
| Volume | 36 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2004 |
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Keywords
- C4BQ0
- familial clustering
- HCV diffusion
- Liver cirrhosis
- MHC class III alleles
ASJC Scopus subject areas
- Gastroenterology
Cite this
C4BQ0 : A genetic marker of familial HCV-related liver cirrhosis. / Pasta, L.; Pietrosi, G.; Marrone, C.; D'Amico, G.; D'Amico, M.; Licata, A.; Misiano, G.; Madonia, S.; Mercadante, F.; Pagliaro, L.
In: Digestive and Liver Disease, Vol. 36, No. 7, 07.2004, p. 471-477.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - C4BQ0
T2 - A genetic marker of familial HCV-related liver cirrhosis
AU - Pasta, L.
AU - Pietrosi, G.
AU - Marrone, C.
AU - D'Amico, G.
AU - D'Amico, M.
AU - Licata, A.
AU - Misiano, G.
AU - Madonia, S.
AU - Mercadante, F.
AU - Pagliaro, L.
PY - 2004/7
Y1 - 2004/7
N2 - Background and methods. Host may have a role in the evolution of chronic HCV liver disease. We performed two cross-sectional prospective studies to evaluate the prevalence of cirrhosis in first degree relatives of patients with cirrhosis and the role of two major histocompatibility complex class III alleles BF and C4 versus HCV as risk factors for familial clustering. Findings. Ninety-three (18.6%) of 500 patients with cirrhosis had at least one cirrhotic first degree relative as compared to 13 (2.6%) of 500 controls, (OR 7.38; CI 4.21-12.9). C4BQO was significantly more frequent in the 93 cirrhotic patients than in 93 cirrhotic controls without familiarity (Hardy-Weinberg equilibrium: χ2 5.76, P = 0.016) and in 20 families with versus 20 without aggregation of HCV related cirrhosis (29.2% versus 11.3%, P = 0.001); the association C4BQO-HCV was found almost only in cirrhotic patients with a family history of liver cirrhosis. Conclusions. Our studies support the value of C4BQO as a risk indicator of familial HCV related cirrhosis.
AB - Background and methods. Host may have a role in the evolution of chronic HCV liver disease. We performed two cross-sectional prospective studies to evaluate the prevalence of cirrhosis in first degree relatives of patients with cirrhosis and the role of two major histocompatibility complex class III alleles BF and C4 versus HCV as risk factors for familial clustering. Findings. Ninety-three (18.6%) of 500 patients with cirrhosis had at least one cirrhotic first degree relative as compared to 13 (2.6%) of 500 controls, (OR 7.38; CI 4.21-12.9). C4BQO was significantly more frequent in the 93 cirrhotic patients than in 93 cirrhotic controls without familiarity (Hardy-Weinberg equilibrium: χ2 5.76, P = 0.016) and in 20 families with versus 20 without aggregation of HCV related cirrhosis (29.2% versus 11.3%, P = 0.001); the association C4BQO-HCV was found almost only in cirrhotic patients with a family history of liver cirrhosis. Conclusions. Our studies support the value of C4BQO as a risk indicator of familial HCV related cirrhosis.
KW - C4BQ0
KW - familial clustering
KW - HCV diffusion
KW - Liver cirrhosis
KW - MHC class III alleles
UR - http://www.scopus.com/inward/record.url?scp=4444223953&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4444223953&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2004.02.007
DO - 10.1016/j.dld.2004.02.007
M3 - Article
C2 - 15285527
AN - SCOPUS:4444223953
VL - 36
SP - 471
EP - 477
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 7
ER -