CA 15-3 in human breast cancer. Comparison with tissue polypeptide antigen (TPA) and carcinoembryonic antigen (CEA)

F. Caponigro, R. V. Iaffaioli, C. Pagliarulo, S. De Placido, G. Frasci, B. Ungaro, E. Matano, A. R. Bianco

Research output: Contribution to journalArticlepeer-review

Abstract

CEA, TPA, CA 15-3 were assayed in 238 patients in follow-up for breast cancer after surgery. Ca 15-3 showed the best sensitivity and specificity; the predictive value of a positive CA 15-3 test was three times higher than CEA and TPA. No association was found between marker positivity and the number of organs involved by metastases. CA 15-3 positivity was significantly associated with visceral rather than soft tissue recurrences; no significant similar association was observed for CEA and TPA. CA 15-3 serum levels were early predictors of relapse in four out of nine patients within a 6-12 month follow-up period.

Original languageEnglish
Pages (from-to)73-76
Number of pages4
JournalInternational Journal of Biological Markers
Volume5
Issue number2
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Immunology
  • Biochemistry

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