Abstract
CEA, TPA, CA 15-3 were assayed in 238 patients in follow-up for breast cancer after surgery. Ca 15-3 showed the best sensitivity and specificity; the predictive value of a positive CA 15-3 test was three times higher than CEA and TPA. No association was found between marker positivity and the number of organs involved by metastases. CA 15-3 positivity was significantly associated with visceral rather than soft tissue recurrences; no significant similar association was observed for CEA and TPA. CA 15-3 serum levels were early predictors of relapse in four out of nine patients within a 6-12 month follow-up period.
| Original language | English |
|---|---|
| Pages (from-to) | 73-76 |
| Number of pages | 4 |
| Journal | International Journal of Biological Markers |
| Volume | 5 |
| Issue number | 2 |
| Publication status | Published - 1990 |
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ASJC Scopus subject areas
- Immunology
- Biochemistry
Cite this
CA 15-3 in human breast cancer. Comparison with tissue polypeptide antigen (TPA) and carcinoembryonic antigen (CEA). / Caponigro, F.; Iaffaioli, R. V.; Pagliarulo, C.; De Placido, S.; Frasci, G.; Ungaro, B.; Matano, E.; Bianco, A. R.
In: International Journal of Biological Markers, Vol. 5, No. 2, 1990, p. 73-76.Research output: Contribution to journal › Article
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TY - JOUR
T1 - CA 15-3 in human breast cancer. Comparison with tissue polypeptide antigen (TPA) and carcinoembryonic antigen (CEA)
AU - Caponigro, F.
AU - Iaffaioli, R. V.
AU - Pagliarulo, C.
AU - De Placido, S.
AU - Frasci, G.
AU - Ungaro, B.
AU - Matano, E.
AU - Bianco, A. R.
PY - 1990
Y1 - 1990
N2 - CEA, TPA, CA 15-3 were assayed in 238 patients in follow-up for breast cancer after surgery. Ca 15-3 showed the best sensitivity and specificity; the predictive value of a positive CA 15-3 test was three times higher than CEA and TPA. No association was found between marker positivity and the number of organs involved by metastases. CA 15-3 positivity was significantly associated with visceral rather than soft tissue recurrences; no significant similar association was observed for CEA and TPA. CA 15-3 serum levels were early predictors of relapse in four out of nine patients within a 6-12 month follow-up period.
AB - CEA, TPA, CA 15-3 were assayed in 238 patients in follow-up for breast cancer after surgery. Ca 15-3 showed the best sensitivity and specificity; the predictive value of a positive CA 15-3 test was three times higher than CEA and TPA. No association was found between marker positivity and the number of organs involved by metastases. CA 15-3 positivity was significantly associated with visceral rather than soft tissue recurrences; no significant similar association was observed for CEA and TPA. CA 15-3 serum levels were early predictors of relapse in four out of nine patients within a 6-12 month follow-up period.
UR - http://www.scopus.com/inward/record.url?scp=0025132936&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025132936&partnerID=8YFLogxK
M3 - Article
VL - 5
SP - 73
EP - 76
JO - International Journal of Biological Markers
JF - International Journal of Biological Markers
SN - 0393-6155
IS - 2
ER -