Ca2+ permeability of nicotinic acetylcholine receptors

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Abstract

Nicotinic acetylcholine receptors (nAChRs) are expressed in muscle cells and neurons, as well as in an increasing number of other cell types. The nAChR channels are permeable to cations, including Ca2+. Ca2+ entry through nAChR channels has been shown to modulate several Ca2+-dependent cellular processes, such as neurotransmitter release, synaptic plasticity, and cell motility. The value of Ca2+ permeability associated to a particular nAChR subtype thus represents an important indication for its physiological role. This review summarizes the quantitative data on Ca2+ permeability obtained from several nAChR subtypes in native and heterologous systems. Different experimental approaches are compared, and the structural determinants of Ca2+ permeability are discussed.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalCell Calcium
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 2004

Keywords

  • Ca permeability
  • Fractional Ca current
  • Nicotinic acetylcholine receptors
  • P/P ratio

ASJC Scopus subject areas

  • Cell Biology
  • Endocrinology

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