Ca2+ permeability of nicotinic acetylcholine receptors

Research output: Contribution to journalArticlepeer-review


Nicotinic acetylcholine receptors (nAChRs) are expressed in muscle cells and neurons, as well as in an increasing number of other cell types. The nAChR channels are permeable to cations, including Ca2+. Ca2+ entry through nAChR channels has been shown to modulate several Ca2+-dependent cellular processes, such as neurotransmitter release, synaptic plasticity, and cell motility. The value of Ca2+ permeability associated to a particular nAChR subtype thus represents an important indication for its physiological role. This review summarizes the quantitative data on Ca2+ permeability obtained from several nAChR subtypes in native and heterologous systems. Different experimental approaches are compared, and the structural determinants of Ca2+ permeability are discussed.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalCell Calcium
Issue number1
Publication statusPublished - Jan 2004


  • Ca permeability
  • Fractional Ca current
  • Nicotinic acetylcholine receptors
  • P/P ratio

ASJC Scopus subject areas

  • Cell Biology
  • Endocrinology

Fingerprint Dive into the research topics of 'Ca2+ permeability of nicotinic acetylcholine receptors'. Together they form a unique fingerprint.

Cite this