Ca2+ release induced by cyclic ADP ribose in mice lacking type 3 ryanodine receptor

Rosella Fulceri, Rosetta Rossi, Roberto Bottinelli, Antonio Conti, Elena Intravaia, Antony Galione, Angelo Benedetti, Vincenzo Sorrentino, Carlo Reggiani

Research output: Contribution to journalArticlepeer-review


The action of cyclic-ADP-ribose was studied on calcium release from sarcoplasmic reticulum of skeletal muscles of neonatal and adult wild-type and RyR3-deficient mice. cADPR increased calcium efflux from microsomes, enhanced caffeine-induced calcium release, and, in 20% of the tests, triggered calcium release in single muscle fibers. These responses occurred only in the diaphragm of adult RyR3-deficient mice. cADPR action was abolished by ryanodine, ruthenium red, and 8-brome-cADPR. These results strongly favor a specific action of cADPR on RyR1. The responsiveness of RyR1 appears in adult muscles when RyR3 is lacking.

Original languageEnglish
Pages (from-to)697-702
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - Nov 2 2001


  • CADP-ribose
  • Ryanodine receptors
  • Sarcoplasmic reticulum
  • Single muscle fibers
  • Skeletal muscles

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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