[Ca2+](i) effects of bradykinin B2 receptor activation in PC12 cells

F. Grohovaz; D. Zacchetti; P. D'Andrea; P. Lorenzon; J. Meldolesi

[Ca2+](i) effects of bradykinin B2 receptor activation in PC12 cells

F. Grohovaz, D. Zacchetti, P. D'Andrea, P. Lorenzon, J. Meldolesi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

In PC12 cells, activation of B₂ receptors by bradykinin promotes an elevation of cytosolic Ca²⁺ by two mechanisms: IP3 mediated release of Ca²⁺ from intracellular stores and stimulation of multiple Ca²⁺ influx pathways. Since these events can have different kinetics and spatial localizations they can induce diversified effects in different cell areas.

Original language	English
Pages (from-to)	9-15
Number of pages	7
Journal	Agents and Actions
Volume	38
Issue number	SUPPL. II
Publication status	Published - 1992

ASJC Scopus subject areas

Pharmacology (medical)
Toxicology

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title = "[Ca2+](i) effects of bradykinin B2 receptor activation in PC12 cells",

abstract = "In PC12 cells, activation of B2 receptors by bradykinin promotes an elevation of cytosolic Ca2+ by two mechanisms: IP3 mediated release of Ca2+ from intracellular stores and stimulation of multiple Ca2+ influx pathways. Since these events can have different kinetics and spatial localizations they can induce diversified effects in different cell areas.",

author = "F. Grohovaz and D. Zacchetti and P. D'Andrea and P. Lorenzon and J. Meldolesi",

year = "1992",

language = "English",

volume = "38",

pages = "9--15",

journal = "Inflammation Research",

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AU - Grohovaz, F.

AU - Zacchetti, D.

AU - D'Andrea, P.

AU - Lorenzon, P.

AU - Meldolesi, J.

PY - 1992

Y1 - 1992

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AB - In PC12 cells, activation of B2 receptors by bradykinin promotes an elevation of cytosolic Ca2+ by two mechanisms: IP3 mediated release of Ca2+ from intracellular stores and stimulation of multiple Ca2+ influx pathways. Since these events can have different kinetics and spatial localizations they can induce diversified effects in different cell areas.

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