CADISP-genetics: An International project searching for genetic risk factors of cervical artery dissections

S. Debette, T. M. Metso, A. Pezzini, S. T. Engelter, D. Leys, P. Lyrer, A. J. Metso, T. Brandt, M. Kloss, C. Lichy, I. Hausser, E. Touzé, H. S. Markus, S. Abboud, V. Caso, A. Bersano, A. Grau, A. Altintas, P. Amouyel, T. TatlisumakJ. Dallongeville, C. Grond-Ginsbach, Massimo Pandolfo, Vincent Thijs, Tiina Metso, Antti Metso, Marja Metso, Turgut Tatlisumak, Marie Bodenant, Stéphanie Debette, Didier Leys, Paul Ossou, Fabien Louillet, Jean Louis Mas, Emmanuel Touzé, Sara Leder, Anne Léger, Sandrine Deltour, Sophie Crozier, Isabelle Méresse, Yves Samson, Sandrine Canaple, Olivier Godefroy, Chantal Lamy, Yannick Béjot, Maurice Giroud, Pierre Decavel, Elizabeth Medeiros, Paola Montiel, Thierry Moulin, Fabrice Vuillier, Philippe Amouyel, Jean Dallongeville, Stéphanie Debette, Nathalie Fievet, Laurence Bellengier, Dominique Deplanque, Christian Libersa, Sabrina Schilling, Sylvie Montel, Christine Rémy, Caspar Grond-Ginsbach, Manja Kloss, Christoph Lichy, Tina Wiest, Inge Werner, Marie Luise Arnold, Michael Dos Santos, Armin Grau, Martin Dichgans, Ingrid Hausser, Tobias Brandt, Constanze Thomas-Feles, Ralf Weber, Elisabetta Del Zotto, Alessia Giossi, Alessandro Padovani, Alessandro Pezzini, Valeria Caso, Elena Ballabio, Anna Bersano, Simone Beretta, Carlo Ferrarese, Maria Sessa, Stefano Paolucci, Stefan Engelter, Felix Fluri, Florian Hatz, Dominique Gisler, Annet Tiemessen, Philippe Lyrer, Hugh Markus, Ayse Altintas, Juan Jose Martin

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Cervical artery dissection (CAD) is a frequent cause of ischemic stroke, and occasionally death, in young adults. Several lines of evidence suggest a genetic predisposition to CAD. However, previous genetic studies have been inconclusive mainly due to insufficient numbers of patients. Our hypothesis is that CAD is a multifactorial disease caused by yet largely unidentified genetic variants and environmental factors, which may interact. Our aim is to identify genetic variants associated with an increased risk of CAD and possibly gene-environment interactions. Methods: We organized a multinational European network, Cervical Artery Dissection and Ischemic Stroke Patients (CADISP), which aims at increasing our knowledge of the pathophysiological mechanisms of this disease in a large group of patients. Within this network, we are aiming to perform a de novo genetic association analysis using both a genome-wide and a candidate gene approach. For this purpose, DNA from approximately 1100 patients with CAD, and 2000 healthy controls is being collected. In addition, detailed clinical, laboratory, diagnostic, therapeutic, and outcome data are being collected from all participants applying predefined criteria and definitions in a standardized way. We are expecting to reach the above numbers of subjects by early 2009. Conclusions: We present the strategy of a collaborative project searching for the genetic risk factors of CAD. The CADISP network will provide detailed and novel data on environmental risk factors and genetic susceptibility to CAD.

Original languageEnglish
Pages (from-to)224-230
Number of pages7
JournalInternational Journal of Stroke
Volume4
Issue number3
DOIs
Publication statusPublished - 2009

Keywords

  • Dissection
  • Genetics
  • Ischemic stroke
  • Polymorphisms
  • Risk factors
  • SNP

ASJC Scopus subject areas

  • Neurology

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