Caffeine interferes with morphine-induced hyperactivity but not analgesia

A. Oliverio, C. Castellano, F. Pavone, J. Vetulani

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Abstract

In C57BL/6 mice caffeine antagonized morphine-induced hyperactivity. This effect was most evident when caffeine was used in doses that slightly increased locomotor activity. Given at the same doses caffeine did not affect morphine-induced analgesia. Two possibilities of explanation of this effect are discussed: action of caffeine on dopaminergic mechanisms responsible for morphine-induced running fit through its effect on cyclic AMP level, had a direct action of caffeine on δ opiate receptors involved in the stimulatory effect of morphine.

Original languageEnglish
Pages (from-to)445-449
Number of pages5
JournalPolish Journal of Pharmacology and Pharmacy
Volume35
Issue number6
Publication statusPublished - 1983

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ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Oliverio, A., Castellano, C., Pavone, F., & Vetulani, J. (1983). Caffeine interferes with morphine-induced hyperactivity but not analgesia. Polish Journal of Pharmacology and Pharmacy, 35(6), 445-449.