Abstract
In C57BL/6 mice caffeine antagonized morphine-induced hyperactivity. This effect was most evident when caffeine was used in doses that slightly increased locomotor activity. Given at the same doses caffeine did not affect morphine-induced analgesia. Two possibilities of explanation of this effect are discussed: action of caffeine on dopaminergic mechanisms responsible for morphine-induced running fit through its effect on cyclic AMP level, had a direct action of caffeine on δ opiate receptors involved in the stimulatory effect of morphine.
Original language | English |
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Pages (from-to) | 445-449 |
Number of pages | 5 |
Journal | Polish Journal of Pharmacology and Pharmacy |
Volume | 35 |
Issue number | 6 |
Publication status | Published - 1983 |
ASJC Scopus subject areas
- Pharmaceutical Science
- Pharmacology