Caffeine interferes with morphine-induced hyperactivity but not analgesia

A. Oliverio, C. Castellano, F. Pavone, J. Vetulani

Research output: Contribution to journalArticlepeer-review


In C57BL/6 mice caffeine antagonized morphine-induced hyperactivity. This effect was most evident when caffeine was used in doses that slightly increased locomotor activity. Given at the same doses caffeine did not affect morphine-induced analgesia. Two possibilities of explanation of this effect are discussed: action of caffeine on dopaminergic mechanisms responsible for morphine-induced running fit through its effect on cyclic AMP level, had a direct action of caffeine on δ opiate receptors involved in the stimulatory effect of morphine.

Original languageEnglish
Pages (from-to)445-449
Number of pages5
JournalPolish Journal of Pharmacology and Pharmacy
Issue number6
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology


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