CagA+ Helicobacter pylori infection and gastric cancer risk in the EPIC-EURGAST study

Domenico Palli, Giovanna Masala, Giuseppe Del Giudice, Mario Plebani, Daniela Basso, Duccio Berti, Mattijs E. Numans, Marco Ceroti, Petra H M Peeters, H. Bas Bueno De Mesquita, Frederike L. Buchner, Francoise Clavel-Chapelon, Marie Christine Boutron-Ruault, Vittorio Krogh, Calogero Saieva, Paolo Vineis, Salvatore Panico, Rosario Tumino, Olof Nyrén, Henrik SimánGoran Berglund, Goran Hallmans, Maria Jose Sanchez, Nerea Larrãnaga, Aurelio Barricarte, Carmen Navarro, Jose R. Quiros, Tim Key, Naomi Allen, Sheila Bingham, Kay Tee Khaw, Heiner Boeing, Cornelia Weikert, Jakob Linseisen, Gabriele Nagel, Kim Overvad, Reimar W. Thomsen, Anne Tjonneland, Anja Olsen, Antonia Trichoupoulou, Dimitrios Trichopoulos, Athina Arvaniti, Guillem Pera, Rudolf Kaaks, Mazda Jenab, Pietro Ferrari, Gabriella Nesi, Fatima Carneiro, Elio Riboli, Carlos A. Gonzalez

Research output: Contribution to journalArticlepeer-review


Helicobacter pylori (H. pylori), atrophic gastritis, dietary and lifestyle factors have been associated with gastric cancer (GC). These factors have been evaluated in a large case-control study nested in the European Prospective Investigation into Cancer and Nutrition carried out in 9 countries, including the Mediterranean area. Participants, enrolled in 1992-1998, provided life-style and dietary information and a blood sample (360,000; mean follow-up: 6.1 years). For 233 GC cases diagnosed after enrolment and their 910 controls individually-matched by center, gender, age and blood donation date H. pylori antibodies (antilysate and antiCagA) and plasma Pepsinogen A (PGA) were measured by ELISA methods. Severe chronic atrophic gastritis (SCAG) was defined as PGA circulating levels

Original languageEnglish
Pages (from-to)859-867
Number of pages9
JournalInternational Journal of Cancer
Issue number4
Publication statusPublished - Feb 15 2007


  • Chronic atrophic gastritis
  • Epidemiology
  • Helicobacter pylori
  • Pepsinogen
  • Stomach cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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