Cajal-retzius cell density as marker of type of focal cortical dysplasia

Rita Garbelli, C. Frassoni, A. Ferrario, L. Tassi, M. Bramerio, R. Spreafico

Research output: Contribution to journalArticle

Abstract

Cajal-Retzius cells, identified using calretinin antiserum, were studied in layer I (LI) of adult human temporal cortex from epileptic patients with Taylor's focal cortical dysplasia and architectural dysplasia, in comparison with normal cortex. Both types of dysplasia showed LI hypercellularity, but only in architectural dysplasia was the density of Cajal-Retzius cells significantly increased. A subset of Cajal-Retzius cells were reelin immunoreactive, but none were GABA positive. These findings suggest that differences in the persistence of Cajal-Retzius cells, which probably reflect different types of alteration during brain development, can assist in characterizing different forms of cortical dysplasia.

Original languageEnglish
Pages (from-to)2767-2771
Number of pages5
JournalNeuroReport
Volume12
Issue number12
Publication statusPublished - Aug 28 2001

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Malformations of Cortical Development
Cell Count
Calbindin 2
Temporal Lobe
gamma-Aminobutyric Acid
Immune Sera
Brain

Keywords

  • Cajal-Retzius cells
  • Calretinin
  • GABA
  • Immunocytochemistry
  • Molecular layer
  • Reelin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Garbelli, R., Frassoni, C., Ferrario, A., Tassi, L., Bramerio, M., & Spreafico, R. (2001). Cajal-retzius cell density as marker of type of focal cortical dysplasia. NeuroReport, 12(12), 2767-2771.

Cajal-retzius cell density as marker of type of focal cortical dysplasia. / Garbelli, Rita; Frassoni, C.; Ferrario, A.; Tassi, L.; Bramerio, M.; Spreafico, R.

In: NeuroReport, Vol. 12, No. 12, 28.08.2001, p. 2767-2771.

Research output: Contribution to journalArticle

Garbelli, R, Frassoni, C, Ferrario, A, Tassi, L, Bramerio, M & Spreafico, R 2001, 'Cajal-retzius cell density as marker of type of focal cortical dysplasia', NeuroReport, vol. 12, no. 12, pp. 2767-2771.
Garbelli R, Frassoni C, Ferrario A, Tassi L, Bramerio M, Spreafico R. Cajal-retzius cell density as marker of type of focal cortical dysplasia. NeuroReport. 2001 Aug 28;12(12):2767-2771.
Garbelli, Rita ; Frassoni, C. ; Ferrario, A. ; Tassi, L. ; Bramerio, M. ; Spreafico, R. / Cajal-retzius cell density as marker of type of focal cortical dysplasia. In: NeuroReport. 2001 ; Vol. 12, No. 12. pp. 2767-2771.
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