Calcimimetic and vitamin D analog use in hemodialyzed patients is associated with increased levels of vitamin K dependent proteins

Maria Fusaro; Sandro Giannini; Maurizio Gallieni; Marianna Noale; Giovanni Tripepi; Maurizio Rossini; Piergiorgio Messa; Paolo Rigotti; Tecla Pati; Francesco Barbisoni; Antonio Piccoli; Andrea Aghi; Marianna Alessi; Luciana Bonfante; Fabrizio Fabris; Sabina Zambon; Stefania Sella; Giorgio Iervasi; Mario Plebani

doi:10.1007/s12020-015-0673-z

Calcimimetic and vitamin D analog use in hemodialyzed patients is associated with increased levels of vitamin K dependent proteins

Maria Fusaro, Sandro Giannini, Maurizio Gallieni, Marianna Noale, Giovanni Tripepi, Maurizio Rossini, Piergiorgio Messa, Paolo Rigotti, Tecla Pati, Francesco Barbisoni, Antonio Piccoli, Andrea Aghi, Marianna Alessi, Luciana Bonfante, Fabrizio Fabris, Sabina Zambon, Stefania Sella, Giorgio Iervasi, Mario Plebani

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Matrix Gla protein (MGP) and bone Gla protein (BGP) are two vitamin K-dependent proteins (VKDPs) involved in the regulation of vascular calcification (VC). We carried out a secondary analysis of the VIKI study to evaluate associations between drug consumption and VKDP levels in 387 hemodialyzed patients. The VIKI study assessed the prevalence of vitamin K deficiency in hemodialysis patients. We evaluated drug consumption, determined BGP and MGP levels, and verified the presence of any vertebral fractures (VF) and VC by spine radiographs. Total BGP levels were twice as high with calcimimetics versus no calcimimetics (290 vs. 158.5 mcg/L, p

Original language	English
Pages (from-to)	333-341
Number of pages	9
Journal	Endocrine
Volume	51
Issue number	2
DOIs	https://doi.org/10.1007/s12020-015-0673-z
Publication status	Published - Feb 1 2016

Keywords

Biochemical markers of bone turnover
CKD
Matrix mineralization
Vascular calcification
Vitamin K proteins

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism

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10.1007/s12020-015-0673-z

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Fusaro, M., Giannini, S., Gallieni, M., Noale, M., Tripepi, G., Rossini, M., Messa, P., Rigotti, P., Pati, T., Barbisoni, F., Piccoli, A., Aghi, A., Alessi, M., Bonfante, L., Fabris, F., Zambon, S., Sella, S., Iervasi, G., & Plebani, M. (2016). Calcimimetic and vitamin D analog use in hemodialyzed patients is associated with increased levels of vitamin K dependent proteins. Endocrine, 51(2), 333-341. https://doi.org/10.1007/s12020-015-0673-z

Calcimimetic and vitamin D analog use in hemodialyzed patients is associated with increased levels of vitamin K dependent proteins. / Fusaro, Maria; Giannini, Sandro; Gallieni, Maurizio; Noale, Marianna; Tripepi, Giovanni; Rossini, Maurizio; Messa, Piergiorgio; Rigotti, Paolo; Pati, Tecla; Barbisoni, Francesco; Piccoli, Antonio; Aghi, Andrea; Alessi, Marianna; Bonfante, Luciana; Fabris, Fabrizio; Zambon, Sabina; Sella, Stefania; Iervasi, Giorgio; Plebani, Mario.

In: Endocrine, Vol. 51, No. 2, 01.02.2016, p. 333-341.

Research output: Contribution to journal › Article › peer-review

Fusaro, M, Giannini, S, Gallieni, M, Noale, M, Tripepi, G, Rossini, M, Messa, P, Rigotti, P, Pati, T, Barbisoni, F, Piccoli, A, Aghi, A, Alessi, M, Bonfante, L, Fabris, F, Zambon, S, Sella, S, Iervasi, G & Plebani, M 2016, 'Calcimimetic and vitamin D analog use in hemodialyzed patients is associated with increased levels of vitamin K dependent proteins', Endocrine, vol. 51, no. 2, pp. 333-341. https://doi.org/10.1007/s12020-015-0673-z

Fusaro, Maria ; Giannini, Sandro ; Gallieni, Maurizio ; Noale, Marianna ; Tripepi, Giovanni ; Rossini, Maurizio ; Messa, Piergiorgio ; Rigotti, Paolo ; Pati, Tecla ; Barbisoni, Francesco ; Piccoli, Antonio ; Aghi, Andrea ; Alessi, Marianna ; Bonfante, Luciana ; Fabris, Fabrizio ; Zambon, Sabina ; Sella, Stefania ; Iervasi, Giorgio ; Plebani, Mario. / Calcimimetic and vitamin D analog use in hemodialyzed patients is associated with increased levels of vitamin K dependent proteins. In: Endocrine. 2016 ; Vol. 51, No. 2. pp. 333-341.

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Calcimimetic and vitamin D analog use in hemodialyzed patients is associated with increased levels of vitamin K dependent proteins

Abstract

Keywords

ASJC Scopus subject areas

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