Calcimimetic and vitamin D analog use in hemodialyzed patients is associated with increased levels of vitamin K dependent proteins

Maria Fusaro, Sandro Giannini, Maurizio Gallieni, Marianna Noale, Giovanni Tripepi, Maurizio Rossini, Piergiorgio Messa, Paolo Rigotti, Tecla Pati, Francesco Barbisoni, Antonio Piccoli, Andrea Aghi, Marianna Alessi, Luciana Bonfante, Fabrizio Fabris, Sabina Zambon, Stefania Sella, Giorgio Iervasi, Mario Plebani

Research output: Contribution to journalArticlepeer-review

Abstract

Matrix Gla protein (MGP) and bone Gla protein (BGP) are two vitamin K-dependent proteins (VKDPs) involved in the regulation of vascular calcification (VC). We carried out a secondary analysis of the VIKI study to evaluate associations between drug consumption and VKDP levels in 387 hemodialyzed patients. The VIKI study assessed the prevalence of vitamin K deficiency in hemodialysis patients. We evaluated drug consumption, determined BGP and MGP levels, and verified the presence of any vertebral fractures (VF) and VC by spine radiographs. Total BGP levels were twice as high with calcimimetics versus no calcimimetics (290 vs. 158.5 mcg/L, p 

Original languageEnglish
Pages (from-to)333-341
Number of pages9
JournalEndocrine
Volume51
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Keywords

  • Biochemical markers of bone turnover
  • CKD
  • Matrix mineralization
  • Vascular calcification
  • Vitamin K proteins

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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