Calcite Single Crystals as Hosts for Atomic-Scale Entrapment and Slow Release of Drugs

Giulia Magnabosco, Matteo Di Giosia, Iryna Polishchuk, Eva Weber, Simona Fermani, Andrea Bottoni, Francesco Zerbetto, Pier Giuseppe Pelicci, Boaz Pokroy, Stefania Rapino, Giuseppe Falini, Matteo Calvaresi

Research output: Contribution to journalArticlepeer-review

Abstract

Doxorubicin (DOX)/CaCO3 single crystals act as pH responsive drug carrier. A biomimetic approach demonstrates that calcite single crystals are able, during their growth in the presence of doxorubicin, to entrap drug molecules inside their lattice along specific crystallographic directions. Alterations in lattice dimensions and microstructural parameters are determined by means of high-resolution synchrotron powder diffraction measurements. Confocal microscopy confirms that doxorubicin is uniformly embedded in the crystal and is not simply adsorbed on the crystal surface. A slow release of DOX was obtained preferentially in the proximity of the crystals, targeting cancer cells. The anticancer drug doxorubicin is entrapped inside the lattice of calcite single crystals. High-resolution synchrotron powder diffraction and confocal fluorescence microscopy allow to exactly localize doxorubicin molecules in the calcite crystal. The pH sensitive CaCO3 solubility releases slowly the entrapped molecules in proximity of the crystals, only when the dissolution occurs, targeting cancer cells that uptake the released drug.

Original languageEnglish
Pages (from-to)1510-1516
Number of pages7
JournalAdvanced healthcare materials
Volume4
Issue number10
DOIs
Publication statusPublished - 2015

Keywords

  • Calcium carbonate
  • Doxorubicin
  • Drug carriers
  • High-resolution synchrotron powder diffraction
  • Intracrystalline

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Pharmaceutical Science

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