Calcitonin assay in wash-out fluid after fine-needle aspiration biopsy in patients with a thyroid nodule and border-line value of the hormone

F. Massaro, M. Dolcino, R. Degrandi, D. Ferone, M. Mussap, F. Minuto, M. Giusti

Research output: Contribution to journalArticlepeer-review

Abstract

Assaying calcitonin (CT) in the wash-out fluid from fine-needle aspiration biopsies (CT-FNAB) could be useful in the diagnosis of medullary thyroid carcinoma (MTC). The aim of this study was to correlate serum CT with cytology and CT-FNAB. Twenty-seven subjects (age range 27-75 yr) were studied. FNAB was performed in a thyroid nodule (no.=16) or lymph-node (no.=1 previously operated on for MTC) or in the prevalent nodule of multinodular goiters (no.=10). CT-FNAB values obtained in 37 subjects with normal serum CT (100 ng/l. Our data do not show any correlation between CT-FNAB and serum CT. In conclusion, borderline CT values in patients with thyroid nodules are not rare. Our experience suggests that CT-FNAB does not have the same importance as that reported in the literature for thyroglobulin and PTH assay in wash-out fluid after FNAB in malignant thyroid and hyperfunctioning parathyroid lesions.

Original languageEnglish
Pages (from-to)308-312
Number of pages5
JournalJournal of Endocrinological Investigation
Volume32
Issue number4
Publication statusPublished - Apr 2009

Keywords

  • Calcitonin
  • Fine-needle aspiration biopsy
  • Medullary thyroid carcinoma
  • Thyroid nodule

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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