Calcitonin gene-related peptide immunoreactivity at the human neuromuscular junction

M. Mora, M. Marchi, J. M. Polak, S. J. Gibson, F. Cornelio

Research output: Contribution to journalArticlepeer-review

Abstract

We have studied the presence of calcitonin gene-related peptide (CGRP) immunoreactivity at the human motor end-plate in intercostal muscles from 6 normal subjects. Only a small proportion of end-plates were positively stained in the muscle. Different metabolic states at single motor end-plates or variable rates of CGRP synthesis in separate motoneurones could account for the uneven distribution of CGRP immunoreactivity at the human neuromuscular junction, or else, extremely low amounts of the peptide are below the threshold of sensitivity of the immunofluorescence method used in the present study.

Original languageEnglish
Pages (from-to)404-407
Number of pages4
JournalBrain Research
Volume492
Issue number1-2
DOIs
Publication statusPublished - Jul 17 1989

Keywords

  • Calcitonin gene-related peptide
  • Human neuromuscular junction
  • Immunocytochemistry
  • Neuropeptide
  • Trophic factor

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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