Calcitonin reduces steady ionic current of the growth plate

Isabella Villa, Corrado Sosio, Alessandro De Ponti, Fiorenza Dondi Benelli, Alessandro Rubinacci

Research output: Contribution to journalArticle

Abstract

We tested the hypothesis that calcitonin regulates the electric current associated with ionic exchanges occurring at the growth plate. For this purpose, we measured the net outward current driven by the growth plate of metatarsal bones of weanling mice by means of a voltage-sensitive probe system vibrating in two dimensions. Current density was reduced by calcitonin in a dose-dependent manner. Maximal reduction (-40%) was obtained at a calcitonin concentration of 5 IU/ml. No effect was observed for calcitonin concentrations ≤ 0.05 IU/ml. When chloride was removed from the medium, calcitonin was less effective in reducing the net current density. Neither calcitonin gene-related peptide nor clodronate was able to induce any measurable change of the current density. Our results indicate that calcitonin acts on the ionic exchanges occurring at the growth plate and suggest that endogenous electrical signals in bone might be modulated by hormones.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalElectromagnetic Biology and Medicine
Volume15
Issue number3
Publication statusPublished - 1996

Fingerprint

calcitonin
growth plate
Growth Plate
Calcitonin
bones
Clodronic Acid
electric current
Metatarsal Bones
Calcitonin Gene-Related Peptide
weanlings
Chlorides
chlorides
hormones
Hormones
Bone and Bones
mice
dosage

Keywords

  • Calcitonin
  • Growth plate
  • Ionic current
  • Vibrating probe

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Calcitonin reduces steady ionic current of the growth plate. / Villa, Isabella; Sosio, Corrado; De Ponti, Alessandro; Benelli, Fiorenza Dondi; Rubinacci, Alessandro.

In: Electromagnetic Biology and Medicine, Vol. 15, No. 3, 1996, p. 175-182.

Research output: Contribution to journalArticle

Villa, Isabella ; Sosio, Corrado ; De Ponti, Alessandro ; Benelli, Fiorenza Dondi ; Rubinacci, Alessandro. / Calcitonin reduces steady ionic current of the growth plate. In: Electromagnetic Biology and Medicine. 1996 ; Vol. 15, No. 3. pp. 175-182.
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