Abstract
We tested the hypothesis that calcitonin regulates the electric current associated with ionic exchanges occurring at the growth plate. For this purpose, we measured the net outward current driven by the growth plate of metatarsal bones of weanling mice by means of a voltage-sensitive probe system vibrating in two dimensions. Current density was reduced by calcitonin in a dose-dependent manner. Maximal reduction (-40%) was obtained at a calcitonin concentration of 5 IU/ml. No effect was observed for calcitonin concentrations ≤ 0.05 IU/ml. When chloride was removed from the medium, calcitonin was less effective in reducing the net current density. Neither calcitonin gene-related peptide nor clodronate was able to induce any measurable change of the current density. Our results indicate that calcitonin acts on the ionic exchanges occurring at the growth plate and suggest that endogenous electrical signals in bone might be modulated by hormones.
| Original language | English |
|---|---|
| Pages (from-to) | 175-182 |
| Number of pages | 8 |
| Journal | Electromagnetic Biology and Medicine |
| Volume | 15 |
| Issue number | 3 |
| Publication status | Published - 1996 |
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Keywords
- Calcitonin
- Growth plate
- Ionic current
- Vibrating probe
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
Cite this
Calcitonin reduces steady ionic current of the growth plate. / Villa, Isabella; Sosio, Corrado; De Ponti, Alessandro; Benelli, Fiorenza Dondi; Rubinacci, Alessandro.
In: Electromagnetic Biology and Medicine, Vol. 15, No. 3, 1996, p. 175-182.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Calcitonin reduces steady ionic current of the growth plate
AU - Villa, Isabella
AU - Sosio, Corrado
AU - De Ponti, Alessandro
AU - Benelli, Fiorenza Dondi
AU - Rubinacci, Alessandro
PY - 1996
Y1 - 1996
N2 - We tested the hypothesis that calcitonin regulates the electric current associated with ionic exchanges occurring at the growth plate. For this purpose, we measured the net outward current driven by the growth plate of metatarsal bones of weanling mice by means of a voltage-sensitive probe system vibrating in two dimensions. Current density was reduced by calcitonin in a dose-dependent manner. Maximal reduction (-40%) was obtained at a calcitonin concentration of 5 IU/ml. No effect was observed for calcitonin concentrations ≤ 0.05 IU/ml. When chloride was removed from the medium, calcitonin was less effective in reducing the net current density. Neither calcitonin gene-related peptide nor clodronate was able to induce any measurable change of the current density. Our results indicate that calcitonin acts on the ionic exchanges occurring at the growth plate and suggest that endogenous electrical signals in bone might be modulated by hormones.
AB - We tested the hypothesis that calcitonin regulates the electric current associated with ionic exchanges occurring at the growth plate. For this purpose, we measured the net outward current driven by the growth plate of metatarsal bones of weanling mice by means of a voltage-sensitive probe system vibrating in two dimensions. Current density was reduced by calcitonin in a dose-dependent manner. Maximal reduction (-40%) was obtained at a calcitonin concentration of 5 IU/ml. No effect was observed for calcitonin concentrations ≤ 0.05 IU/ml. When chloride was removed from the medium, calcitonin was less effective in reducing the net current density. Neither calcitonin gene-related peptide nor clodronate was able to induce any measurable change of the current density. Our results indicate that calcitonin acts on the ionic exchanges occurring at the growth plate and suggest that endogenous electrical signals in bone might be modulated by hormones.
KW - Calcitonin
KW - Growth plate
KW - Ionic current
KW - Vibrating probe
UR - http://www.scopus.com/inward/record.url?scp=2542565097&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2542565097&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:2542565097
VL - 15
SP - 175
EP - 182
JO - Electromagnetic Biology and Medicine
JF - Electromagnetic Biology and Medicine
SN - 1536-8378
IS - 3
ER -