Calcium and phosphate control by dialysis treatments

Piergiorgio Messa, Roberta Cerutti, Brigida Brezzi, Carlo Alfieri, Mario Cozzolino

Research output: Contribution to journalArticlepeer-review


Calcium and phosphate changes, besides their involvement in bone disease, have been claimed to also be involved in the increased vascular morbidity and mortality of dialysis patients. Even after the recent advances of therapeutic options, their control still remains a challenging problem. Dialysis treatment is a basic approach to the control of these two electrolytes. Calcium control by dialysis is mainly dependent on its mass balance, which is variably influenced by the calcium concentration difference between blood and dialysis solutions (either dialysate or infusion fluids) and by the duration of the treatment. There is no full agreement on the ideal calcium concentration in dialysis fluids, since this choice is also mostly influenced by the concomitant medical therapy. However, there is some consensus in suggesting a lower calcium concentration in standard hemodialysis (HD) treatment (1.25-1.50 mmol/l) than in dialysis treatments characterized by high convective transport. In peritoneal dialysis, calcium balance is affected by its blood dialysate concentration difference and dialysate glucose concentration, with ideal calcium concentration probably being >1.25 and

Original languageEnglish
Pages (from-to)360-368
Number of pages9
JournalBlood Purification
Issue number4
Publication statusPublished - May 2009


  • Calcium
  • Dialysis
  • Phosphate
  • Secondary hyperparathyroidism

ASJC Scopus subject areas

  • Nephrology
  • Hematology


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