Calcium, calcium antagonists and experimental atherosclerosis.

R. Paoletti, A. Corsini, M. R. Soma, F. Bernini

Research output: Contribution to journalArticlepeer-review


Several calcium entry blockers have shown an antiatherosclerotic effect both in vitro and in vivo. The effects are particularly evident against smooth muscle cell migration multiplication, matrix formation, calcium and cholesterol accumulation. Among the new calcium antagonists, isradipine, amlodipine and lacidipine, are promising as antiatherosclerotic agents. Lacidipine is particularly interesting because of its lipophylic structure and accumulation in cell membranes. Lacidipine is structurally related to nifedipine; we observed that lacidipine inhibits three major processes of atherogenesis: cholesteryl ester metabolism in macrophages, proliferation of myocytes, and their migration.

Original languageEnglish
Pages (from-to)12-15
Number of pages4
JournalBlood Pressure, Supplement
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine


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