TY - JOUR
T1 - Calcium, dairy products, and the risk of prostate cancer
AU - Tavani, Alessandra
AU - Gallus, Silvano
AU - Franceschi, Silvia
AU - Vecchia, Carlo L.
PY - 2001/7/1
Y1 - 2001/7/1
N2 - Background. Calcium intake has been suggested to play a role in the etiology of prostate cancer, since it is inversely related to vitamin D levels, which, in turn, would have an antiproliferative effect on human cancer cell lines. The hypothesis that high calcium and low vitamin D levels are associated with prostate cancer risk, however, remains unconvincingly demonstrated. Methods. This relation was investigated in a case-control study of prostate cancer conducted in Northern Italy between 1985 and 1992 on 288 cases and 762 controls admitted to hospital for acute non-neoplastic diseases. Results. No significant relation was found for calcium intake: compared to the lowest quintile of intake, the multivariate odds ratios (OR) of prostatic cancer, after adjusting for age, study center, education, body mass index, and meat intake, for increasing intake quintiles were 1.21, 0.68, 0.64, 1.12, with no trend in risk. The OR was 0.99 for an increment of 500 mg per day of calcium. The risk estimates were consistent in two strata of age (
AB - Background. Calcium intake has been suggested to play a role in the etiology of prostate cancer, since it is inversely related to vitamin D levels, which, in turn, would have an antiproliferative effect on human cancer cell lines. The hypothesis that high calcium and low vitamin D levels are associated with prostate cancer risk, however, remains unconvincingly demonstrated. Methods. This relation was investigated in a case-control study of prostate cancer conducted in Northern Italy between 1985 and 1992 on 288 cases and 762 controls admitted to hospital for acute non-neoplastic diseases. Results. No significant relation was found for calcium intake: compared to the lowest quintile of intake, the multivariate odds ratios (OR) of prostatic cancer, after adjusting for age, study center, education, body mass index, and meat intake, for increasing intake quintiles were 1.21, 0.68, 0.64, 1.12, with no trend in risk. The OR was 0.99 for an increment of 500 mg per day of calcium. The risk estimates were consistent in two strata of age (
KW - Calcium intake
KW - Case-control study
KW - Cheese intake
KW - Milk intake
KW - Prostate cancer
KW - Risk factors
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U2 - 10.1002/pros.1087
DO - 10.1002/pros.1087
M3 - Article
C2 - 11433421
AN - SCOPUS:0035399470
VL - 48
SP - 118
EP - 121
JO - Prostate
JF - Prostate
SN - 0270-4137
IS - 2
ER -