Calcium-dependent regulation of genetically determined spike and waves by the reticular thalamic nucleus of rats

G. Avanzini, M. Vergnes, R. Spreafico, C. Marescaux, P. Genton, A. Portera- Sanchez, C. K. Benninger

Research output: Contribution to journalArticlepeer-review

Abstract

The pathophysiologic role of the reticular thalamic nucleus (RT) in rat generalized nonconvulsive epilepsy was investigated in the selected strain GAERS (genetic absence epilepsy rats from Strasbourg). After the RT was lesioned by the excitotoxic agent ibotenic acid stereotaxically injected in previously callosotomized rats, a disruption of ipsilateral spike and wave discharges (SWD) was observed in freely moving animals. In a second group of animals Cd2+ (0.5-1.5 μl, 1 mM), which is known to block Ca2+ and Ca2+-dependent K+ conductances (gK+ ((Ca2+))), was injected into the thalamus. Cd2+ reversibly suppressed ipsilateral SWD when injected in RT, whereas it slightly reduced SWD expression when injected in the ventrobasal (VB) complex. The difference was highly significant. We conclude that Ca2+- dependent oscillatory properties of the RT are critical for expression of genetically determined SWD in GAERS.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalEpilepsia
Volume34
Issue number1
DOIs
Publication statusPublished - 1993

Keywords

  • Genetic epilepsy
  • Neurologic models
  • Reticular thalamic nucleus
  • Thalamus

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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