Calcium Deposition and Associated Chronic Diseases (Atherosclerosis, Diffuse Idiopathic Skeletal Hyperostosis, and Others)

Fabiola Atzeni, Piercarlo Sarzi-Puttini, Maorizio Bevilacqua

Research output: Contribution to journalArticle

Abstract

Extracellular matrix mineralization or calcification occurs in many pathologic conditions, including atherosclerosis, medial wall calcification, diffuse idiopathic skeletal hyperostosis, and chondrocalcinosis. Vascular wall calcification is the most common and involves two mechanisms: passive calcification resulting from breakdown of the protection system and active calcification resulting from transdifferentiation of mesenchymal cells in the vascular wall to bone. Although reports are conflicting, several matrix proteins are identified as protective factors against dystrophic calcification in nonosseous tissues. Serum matrix Gla protein may be a marker of osteometabolic syndromes that cause hyperostosis and plays a role in Milwaukee shoulder syndrome.

Original languageEnglish
Pages (from-to)413-426
Number of pages14
JournalRheumatic Disease Clinics of North America
Volume32
Issue number2
DOIs
Publication statusPublished - May 2006

Fingerprint

Cell Transdifferentiation
Diffuse Idiopathic Skeletal Hyperostosis
Chondrocalcinosis
Hyperostosis
Vascular Calcification
Extracellular Matrix
Blood Vessels
Atherosclerosis
Calcium
Bone and Bones
Serum
Proteins
matrix Gla protein
Protective Factors
Rotator Cuff Tear Arthropathy

ASJC Scopus subject areas

  • Rheumatology

Cite this

Calcium Deposition and Associated Chronic Diseases (Atherosclerosis, Diffuse Idiopathic Skeletal Hyperostosis, and Others). / Atzeni, Fabiola; Sarzi-Puttini, Piercarlo; Bevilacqua, Maorizio.

In: Rheumatic Disease Clinics of North America, Vol. 32, No. 2, 05.2006, p. 413-426.

Research output: Contribution to journalArticle

Atzeni, Fabiola ; Sarzi-Puttini, Piercarlo ; Bevilacqua, Maorizio. / Calcium Deposition and Associated Chronic Diseases (Atherosclerosis, Diffuse Idiopathic Skeletal Hyperostosis, and Others). In: Rheumatic Disease Clinics of North America. 2006 ; Vol. 32, No. 2. pp. 413-426.
@article{b6ac236822ae4efbb75f01f6bd4e7913,
title = "Calcium Deposition and Associated Chronic Diseases (Atherosclerosis, Diffuse Idiopathic Skeletal Hyperostosis, and Others)",
abstract = "Extracellular matrix mineralization or calcification occurs in many pathologic conditions, including atherosclerosis, medial wall calcification, diffuse idiopathic skeletal hyperostosis, and chondrocalcinosis. Vascular wall calcification is the most common and involves two mechanisms: passive calcification resulting from breakdown of the protection system and active calcification resulting from transdifferentiation of mesenchymal cells in the vascular wall to bone. Although reports are conflicting, several matrix proteins are identified as protective factors against dystrophic calcification in nonosseous tissues. Serum matrix Gla protein may be a marker of osteometabolic syndromes that cause hyperostosis and plays a role in Milwaukee shoulder syndrome.",
author = "Fabiola Atzeni and Piercarlo Sarzi-Puttini and Maorizio Bevilacqua",
year = "2006",
month = "5",
doi = "10.1016/j.rdc.2006.02.003",
language = "English",
volume = "32",
pages = "413--426",
journal = "Rheumatic Disease Clinics of North America",
issn = "0889-857X",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Calcium Deposition and Associated Chronic Diseases (Atherosclerosis, Diffuse Idiopathic Skeletal Hyperostosis, and Others)

AU - Atzeni, Fabiola

AU - Sarzi-Puttini, Piercarlo

AU - Bevilacqua, Maorizio

PY - 2006/5

Y1 - 2006/5

N2 - Extracellular matrix mineralization or calcification occurs in many pathologic conditions, including atherosclerosis, medial wall calcification, diffuse idiopathic skeletal hyperostosis, and chondrocalcinosis. Vascular wall calcification is the most common and involves two mechanisms: passive calcification resulting from breakdown of the protection system and active calcification resulting from transdifferentiation of mesenchymal cells in the vascular wall to bone. Although reports are conflicting, several matrix proteins are identified as protective factors against dystrophic calcification in nonosseous tissues. Serum matrix Gla protein may be a marker of osteometabolic syndromes that cause hyperostosis and plays a role in Milwaukee shoulder syndrome.

AB - Extracellular matrix mineralization or calcification occurs in many pathologic conditions, including atherosclerosis, medial wall calcification, diffuse idiopathic skeletal hyperostosis, and chondrocalcinosis. Vascular wall calcification is the most common and involves two mechanisms: passive calcification resulting from breakdown of the protection system and active calcification resulting from transdifferentiation of mesenchymal cells in the vascular wall to bone. Although reports are conflicting, several matrix proteins are identified as protective factors against dystrophic calcification in nonosseous tissues. Serum matrix Gla protein may be a marker of osteometabolic syndromes that cause hyperostosis and plays a role in Milwaukee shoulder syndrome.

UR - http://www.scopus.com/inward/record.url?scp=33646568804&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646568804&partnerID=8YFLogxK

U2 - 10.1016/j.rdc.2006.02.003

DO - 10.1016/j.rdc.2006.02.003

M3 - Article

C2 - 16716887

AN - SCOPUS:33646568804

VL - 32

SP - 413

EP - 426

JO - Rheumatic Disease Clinics of North America

JF - Rheumatic Disease Clinics of North America

SN - 0889-857X

IS - 2

ER -