Calcium metabolism serum markers in adult patients with epilepsy and the effect of vitamin D supplementation on seizure control

Mario Tombini, Andrea Palermo, Giovanni Assenza, Giovanni Pellegrino, Antonella Benvenga, Chiara Campana, Anda Mihaela Naciu, Federica Assenza, Vincenzo Di Lazzaro

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: To evaluate serum markers of calcium metabolism in adult patients with epilepsy (PWE) treated with antiepileptic drugs (AEDs) and the effect of vitamin D supplementation on seizure frequency. Methods: Serum levels of calcium, phosphate, intact parathyroid hormone (iPTH) and 25-hydroxyvitamin D (25[OH]D) were compared in 160 PWE on chronic therapy with AEDs and 42 matched controls. Blood concentrations were analyzed taking into account the different features of epilepsy and treatment. Finally, the effect of vitamin D supplementation on seizure control was assessed in a subgroup of 48 drug resistant epileptic patients. Results: PWE showed lower serum levels of 25[OH]D compared to control subjects (p <.001). Only 25% PWE showed normal 25[OH]D levels, whereas 41,9% had a vitamin D failure and 33,1% a vitamin D deficiency (p <.001). 25[OH]D serum levels depended on treatment duration, number of medications and enzyme-inducing AEDs (p <.001, p <.001, p =.013, respectively). Polytherapy and enzyme-inducing AEDs showed more detrimental effects on the 25[OH]D and calcium serum levels. The administration of vitamin D failed to significantly improve seizure control. Conclusions: PWE show deficiency of vitamin D. The serum levels of 25[OH]D depend on the features and duration of AEDs treatment. Vitamin D administration in drug resistant epilepsy patients does not result in a reduction of seizure frequency.

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalSeizure
Volume58
DOIs
Publication statusPublished - May 1 2018

Fingerprint

Vitamin D
Epilepsy
Seizures
Biomarkers
Calcium
Anticonvulsants
Serum
Vitamin D Deficiency
Enzymes
Therapeutics
Parathyroid Hormone
Pharmaceutical Preparations

Keywords

  • Antiepileptic drugs
  • Calcium metabolism
  • Seizures
  • Vitamin D

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Calcium metabolism serum markers in adult patients with epilepsy and the effect of vitamin D supplementation on seizure control. / Tombini, Mario; Palermo, Andrea; Assenza, Giovanni; Pellegrino, Giovanni; Benvenga, Antonella; Campana, Chiara; Naciu, Anda Mihaela; Assenza, Federica; Lazzaro, Vincenzo Di.

In: Seizure, Vol. 58, 01.05.2018, p. 75-81.

Research output: Contribution to journalArticle

Tombini, Mario ; Palermo, Andrea ; Assenza, Giovanni ; Pellegrino, Giovanni ; Benvenga, Antonella ; Campana, Chiara ; Naciu, Anda Mihaela ; Assenza, Federica ; Lazzaro, Vincenzo Di. / Calcium metabolism serum markers in adult patients with epilepsy and the effect of vitamin D supplementation on seizure control. In: Seizure. 2018 ; Vol. 58. pp. 75-81.
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AU - Tombini, Mario

AU - Palermo, Andrea

AU - Assenza, Giovanni

AU - Pellegrino, Giovanni

AU - Benvenga, Antonella

AU - Campana, Chiara

AU - Naciu, Anda Mihaela

AU - Assenza, Federica

AU - Lazzaro, Vincenzo Di

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N2 - Purpose: To evaluate serum markers of calcium metabolism in adult patients with epilepsy (PWE) treated with antiepileptic drugs (AEDs) and the effect of vitamin D supplementation on seizure frequency. Methods: Serum levels of calcium, phosphate, intact parathyroid hormone (iPTH) and 25-hydroxyvitamin D (25[OH]D) were compared in 160 PWE on chronic therapy with AEDs and 42 matched controls. Blood concentrations were analyzed taking into account the different features of epilepsy and treatment. Finally, the effect of vitamin D supplementation on seizure control was assessed in a subgroup of 48 drug resistant epileptic patients. Results: PWE showed lower serum levels of 25[OH]D compared to control subjects (p <.001). Only 25% PWE showed normal 25[OH]D levels, whereas 41,9% had a vitamin D failure and 33,1% a vitamin D deficiency (p <.001). 25[OH]D serum levels depended on treatment duration, number of medications and enzyme-inducing AEDs (p <.001, p <.001, p =.013, respectively). Polytherapy and enzyme-inducing AEDs showed more detrimental effects on the 25[OH]D and calcium serum levels. The administration of vitamin D failed to significantly improve seizure control. Conclusions: PWE show deficiency of vitamin D. The serum levels of 25[OH]D depend on the features and duration of AEDs treatment. Vitamin D administration in drug resistant epilepsy patients does not result in a reduction of seizure frequency.

AB - Purpose: To evaluate serum markers of calcium metabolism in adult patients with epilepsy (PWE) treated with antiepileptic drugs (AEDs) and the effect of vitamin D supplementation on seizure frequency. Methods: Serum levels of calcium, phosphate, intact parathyroid hormone (iPTH) and 25-hydroxyvitamin D (25[OH]D) were compared in 160 PWE on chronic therapy with AEDs and 42 matched controls. Blood concentrations were analyzed taking into account the different features of epilepsy and treatment. Finally, the effect of vitamin D supplementation on seizure control was assessed in a subgroup of 48 drug resistant epileptic patients. Results: PWE showed lower serum levels of 25[OH]D compared to control subjects (p <.001). Only 25% PWE showed normal 25[OH]D levels, whereas 41,9% had a vitamin D failure and 33,1% a vitamin D deficiency (p <.001). 25[OH]D serum levels depended on treatment duration, number of medications and enzyme-inducing AEDs (p <.001, p <.001, p =.013, respectively). Polytherapy and enzyme-inducing AEDs showed more detrimental effects on the 25[OH]D and calcium serum levels. The administration of vitamin D failed to significantly improve seizure control. Conclusions: PWE show deficiency of vitamin D. The serum levels of 25[OH]D depend on the features and duration of AEDs treatment. Vitamin D administration in drug resistant epilepsy patients does not result in a reduction of seizure frequency.

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