Calcium phosphate ceramics as drug-delivery system for anticancer therapy

Elena Landi, L. Orlandi, G. Spagna, A. Tampieri, N. Zaffaroni

Research output: Contribution to journalArticlepeer-review

Abstract

In the present paper the synthesis of β-TCP powder and the design of porous and dense ceramics blocks to be used as drug delivery system were examined. Powder and material preparation methodologies were carefully investigated: 5-fluorouracil (5-FU) was loaded on TCP porous and dense blocks and compacted powders using a vacuum adsorption technique and the addition of various organic fillers to modulate the release kinetic was performed. Our results show that the release can be modulated between 2 and 30 days depending on the different combinations of experimental variables (ceramic microstructure, organic additives, drug load, etc).

Original languageEnglish
Pages (from-to)901-904
Number of pages4
JournalKey Engineering Materials
Volume192-195
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Ceramics and Composites

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