Calibration of gamma camera systems for a multicentre European 123I-FP-CIT SPECT normal database

Livia Tossici-Bolt, John C. Dickson, Terez Sera, Robin De Nijs, Maria Claudia Bagnara, Catherine Jonsson, Egon Scheepers, Felicia Zito, Anita Seese, Pierre Malick Koulibaly, Ozlem L. Kapucu, Michel Koole, Maria Raith, Jean George, Markus Nowak Lonsdale, Wolfgang Münzing, Klaus Tatsc, Andrea Varrone

Research output: Contribution to journalArticlepeer-review


Purpose A joint initiative of the European Association of Nuclear Medicine (EANM) Neuroimaging Committee and EANM Research Ltd. aimed to generate a European database of [123I]FP-CIT single photon emission computed tomography (SPECT) scans of healthy controls. This study describes the characterization and harmonization of the imaging equipment of the institutions involved. Methods 123I SPECT images of a striatal phantom filled with striatal to background ratios between 10:1 and 1:1 were acquired on all the gamma cameras with absolute ratios measured from aliquots. The images were reconstructed by a core lab using ordered subset expectation maximization (OSEM) without corrections (NC), with attenuation correction only (AC) and additional scatter and septal penetration correction (ACSC) using the triple energy window method. A quantitative parameter, the simulated specific binding ratio (sSBR), was measured using the "Southampton" methodology that accounts for the partial volume effect and compared against the actual values obtained from the aliquots. Camera-specific recovery coefficients were derived from linear regression and the error of the measurements was evaluated using the coefficient of variation (COV). Results The relationship between measured and actual sSBRs was linear across all systems. Variability was observed between different manufacturers and, to a lesser extent, between cameras of the same type. The NC and AC measurements were found to underestimate systematically the actual sSBRs, while the ACSC measurements resulted in recovery coefficients close to 100% for all cameras (AC range 69-89%, ACSC range 87-116%). The COV improved from 46% (NC) to 32% (AC) and to 14% (ACSC) (p

Original languageEnglish
Pages (from-to)1529-1540
Number of pages12
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Issue number8
Publication statusPublished - Aug 2011


  • I-FP-CIT
  • Normal database
  • Striatal phantom

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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