CALLA-negative, TdT- and CD7-positive acute lymphoblastic leukemia: A phenotype associated with poor prognosis

G. De Rossi, M. A. Aloe Spiriti, A. Cafolla, R. Gastaldi, F. Lo Coco, M. Lopez, M. Luciani, D. Pasqualetti, A. M. Testi, F. Mandelli

Research output: Contribution to journalArticle

Abstract

Eight ALL patients displaying a CD7+, TdT+, CD10-, T MoAbs-, myeloid MoAbs-, AP+ phenotype are described. Some patients showed well-known risk factors such as cytogenetic abnormalities, high WBC count, mediastinal mass, and/or organomegalies. The clinical behaviour was very poor and only one patient is in CR and off therapy. Therefore such a pre-T phenotype, although sometimes associated with the other risk factors, could be considered a poor prognosis phenotype.

Original languageEnglish
Pages (from-to)140-143
Number of pages4
JournalDiagnostic and Clinical Immunology
Volume5
Issue number3
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    De Rossi, G., Aloe Spiriti, M. A., Cafolla, A., Gastaldi, R., Lo Coco, F., Lopez, M., Luciani, M., Pasqualetti, D., Testi, A. M., & Mandelli, F. (1987). CALLA-negative, TdT- and CD7-positive acute lymphoblastic leukemia: A phenotype associated with poor prognosis. Diagnostic and Clinical Immunology, 5(3), 140-143.