PATTERNS CALORIMETRICI IN CORSO DI CIRROSI EPATICA: EFFETTI DELLA MALNUTRIZIONE

Translated title of the contribution: Calorimetric patterns in cirrhotic patients: Effects of malnutrition

C. Panella, F. W. Guglielmi, T. Mastronuzzi, L. Laddaga, F. De Marco, F. Contento, A. Balestrazzi, A. Francavilla

Research output: Contribution to journalArticlepeer-review

Abstract

Indirect calorimetry (IC) is the most simple and sensitive procedure to study metabolism. Energy requirements and substrate oxidation are estimated starting from oxygen (O2) and carbon dioxide (CO2) exchange measurements. Previous studies using IC, revealed that basal energy expenditure (BEE) were similar in overnight fasted normal subjects and overnight cirrhotic patients, and that respiratory quotient (RQ) and substrate oxidation rate of overnight fasted patients were comparable with those of healthy volunteers after 72h of starvation. The aim of this study was to correlate the nutritional and metabolic state in 17 cirrhotic patients and in 6 controls (contr). Anthropometric parameters were used to determine nutritional state, while IC was utilized to define the metabolic state in long-term study with a canopy system. Six malnourished patients (cirrM) were selected because a sensitive (p <0.0005) reduction of body weight (kg) = Pat (59 ± 8) and fat mass (kg) = FM (9.1 ± 2) compared to wellnourished patients = cirrB (Pat = 76 ± 13, FM = 22.8 ± 8 kg) and contr (Pat = 70 ± 14, FM = 17.3 ± 1 kg). Energy production rate = EPR (kcal/day) in patients was independent of nutritional state (cirrB = 1473 ± 271, cirrM = 1459 ± 183 kcal/day) and it was similar to the one registered in healthy people (1491 ± 219 kcal/day). These data were also confirmed when we normalized the EPR (kcal/kg/die) by the metabolically active body mass, the fat free mass (FFM) (contr = 30.0 ± 3, cirrB = 27.7 ± 5, cirrM = 29.5 + 3 kcal/kg/day). More interesting was the data regarding RQ. In our experience, in fact, the sensitive (p <0.0001) changes in substrate oxidation (cirrB RQ 0.83 ± 0.03; cirrM RQ 0.76 ± 0.02, contr RQ 0.85 ± 0.05) were observed only in patients with malnutrition.

Translated title of the contributionCalorimetric patterns in cirrhotic patients: Effects of malnutrition
Original languageItalian
Pages (from-to)15-21
Number of pages7
JournalRivista Italiana di Nutrizione Parenterale ed Enterale
Volume10
Issue number1
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Food Science
  • Anatomy
  • Critical Care and Intensive Care Medicine
  • Nutrition and Dietetics

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