(Ca+Mg)ATPase and calcium influx in erythrocytes of patients with idiopathic hypercalciuria

Giuseppe Vezzoli, Maria Cristina Reina, Simona Zerbi, Renato Spaventa, Laura Soldati, Daniele Cusi, Giuseppe Bianchi

Research output: Contribution to journalArticlepeer-review


Increased erythrocyte (Ca+Mg)ATPase activity was previously observed in idiopathic hypercalciuria. In order to verify if this alteration is a primary or a secondary event, we studied Sr influx in erythrocytes from subjects with idiopathic hypercalciuria. (Ca+Mg)ATPase activity was significantly higher in hypercalciuric than in normocalciuric subjects whereas no difference in Sr influx was found between the two groups. (Ca+Mg)ATPase activity positively correlated with the erythrocyte Sr content found after 5 min of incubation and with urine Ca excretion. The normal Sr permeability suggests that (Ca+Mg)ATPase is primarily altered in idiopathic hypercalciuria. The primary increase of (Ca+Mg)ATPase activity may enhance passive Ca influx by reduction of cellular Ca concentration. It may induce a defect in cellular Ca metabolism that may cause idiopathic hypercalciuria by stimulating bone Ca turn-over and enteral Ca absorption.

Original languageEnglish
Pages (from-to)1099-1104
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology


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