CAMP levels in reactive tissues around dimethylpolysiloxane solid implants

Angela Faga, Mario Merlino

Research output: Contribution to journalArticlepeer-review


By the aid of radioimmunologic assay, the authors measured the cAMP content of the reactive capsules around solid dimethylpolysiloxane implants in mice at different times; they also measured the same substance in some human connective tissues (granulation tissue and normal dermis) and compared together all the values they obtained. Different concentrations of cAMP in different tissues seem to reflect correspondent histologic findings, since they vary according to them. These values also seem to indicate a close correspondence between the development of the process of wound healing and of the foreign-body reaction following the implantation of al-loplastic materials. On the basis of these data, the authors suggest an experimental therapeutic trial to enhance peripheral AMP synthesis in order to control the process of reactive capsule constitution.

Original languageEnglish
Pages (from-to)570-573
Number of pages4
JournalPlastic and Reconstructive Surgery
Issue number4
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Surgery


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