Abstract
Sudden unexplained death (SUD), autopsy-negative deaths occurring after the first year of life, and sudden infant death syndrome (SIDS), deaths occurring in the first year of life, both present major challenges for the medical profession. Tester and Ackerman has presented compelling data implicating a cardiac channelopathy as the pathogenic basis SUDs, with mutations related to long QT syndrome (LQTS). They have revealed that at least one-third of sudden and unexplained deaths in the young have a genetic origin attributable to two life-threatening conditions, LQTS, and catecholaminergic ventricular tachycardia (CPVT). The ECG screening of family members can identify other affected family members with QT prolongation, and genotyping of the proband would allow the recognition of silent mutation carriers within the extended families.
| Original language | English |
|---|---|
| Pages (from-to) | 247-249 |
| Number of pages | 3 |
| Journal | Journal of the American College of Cardiology |
| Volume | 49 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 16 2007 |
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ASJC Scopus subject areas
- Nursing(all)
Cite this
Can a Message From the Dead Save Lives?**Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology. / Schwartz, Peter J.; Crotti, Lia.
In: Journal of the American College of Cardiology, Vol. 49, No. 2, 16.01.2007, p. 247-249.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Can a Message From the Dead Save Lives?**Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
AU - Schwartz, Peter J.
AU - Crotti, Lia
PY - 2007/1/16
Y1 - 2007/1/16
N2 - Sudden unexplained death (SUD), autopsy-negative deaths occurring after the first year of life, and sudden infant death syndrome (SIDS), deaths occurring in the first year of life, both present major challenges for the medical profession. Tester and Ackerman has presented compelling data implicating a cardiac channelopathy as the pathogenic basis SUDs, with mutations related to long QT syndrome (LQTS). They have revealed that at least one-third of sudden and unexplained deaths in the young have a genetic origin attributable to two life-threatening conditions, LQTS, and catecholaminergic ventricular tachycardia (CPVT). The ECG screening of family members can identify other affected family members with QT prolongation, and genotyping of the proband would allow the recognition of silent mutation carriers within the extended families.
AB - Sudden unexplained death (SUD), autopsy-negative deaths occurring after the first year of life, and sudden infant death syndrome (SIDS), deaths occurring in the first year of life, both present major challenges for the medical profession. Tester and Ackerman has presented compelling data implicating a cardiac channelopathy as the pathogenic basis SUDs, with mutations related to long QT syndrome (LQTS). They have revealed that at least one-third of sudden and unexplained deaths in the young have a genetic origin attributable to two life-threatening conditions, LQTS, and catecholaminergic ventricular tachycardia (CPVT). The ECG screening of family members can identify other affected family members with QT prolongation, and genotyping of the proband would allow the recognition of silent mutation carriers within the extended families.
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U2 - 10.1016/j.jacc.2006.10.009
DO - 10.1016/j.jacc.2006.10.009
M3 - Article
VL - 49
SP - 247
EP - 249
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 2
ER -