TY - JOUR
T1 - Can a single low-intensity premature stimulus induce ventricular arrhythmias in the normal heart?
AU - Rossi, Stefano
AU - Baruffi, Silvana
AU - Callegari, Sergio
AU - Carnevali, Luca
AU - Corradi, Domenico
AU - Miragoli, Michele
AU - Musso, Ezio
AU - Sgoifo, Andrea
AU - Trombini, Mimosa
AU - Macchi, Emilio
PY - 2014
Y1 - 2014
N2 - Previously, we observed that a single low-intensity premature ventricular stimulation could occasionally induce spontaneous ectopic beats in normal rat hearts. Possible hypothesis for the arrhythmia is that a premature beat can encounter a zone of conduction block to initiate reentry. However, enhanced dispersion of repolarization, a necessary condition for initiation of reentry, is unlikely to be present in normal myocardium. Thus, the main objective of the present study was to perform detailed pace mapping measurements in normal ventricular myocardium with a view to identify pacing sites and critical coupling intervals which could induce spontaneous ectopic beats and to characterize the reentrant circuits.
AB - Previously, we observed that a single low-intensity premature ventricular stimulation could occasionally induce spontaneous ectopic beats in normal rat hearts. Possible hypothesis for the arrhythmia is that a premature beat can encounter a zone of conduction block to initiate reentry. However, enhanced dispersion of repolarization, a necessary condition for initiation of reentry, is unlikely to be present in normal myocardium. Thus, the main objective of the present study was to perform detailed pace mapping measurements in normal ventricular myocardium with a view to identify pacing sites and critical coupling intervals which could induce spontaneous ectopic beats and to characterize the reentrant circuits.
KW - Arrhythmia
KW - Conduction block
KW - Premature stimulation
KW - Reentry circuit
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U2 - 10.4081/jbr.2014.2128
DO - 10.4081/jbr.2014.2128
M3 - Article
AN - SCOPUS:84959253736
VL - 87
JO - Journal of Biological Research (Italy)
JF - Journal of Biological Research (Italy)
SN - 1826-8838
IS - 1
M1 - 2128
ER -