Can a single low-intensity premature stimulus induce ventricular arrhythmias in the normal heart?

Stefano Rossi, Silvana Baruffi, Sergio Callegari, Luca Carnevali, Domenico Corradi, Michele Miragoli, Ezio Musso, Andrea Sgoifo, Mimosa Trombini, Emilio Macchi

Research output: Contribution to journalArticle

Abstract

Previously, we observed that a single low-intensity premature ventricular stimulation could occasionally induce spontaneous ectopic beats in normal rat hearts. Possible hypothesis for the arrhythmia is that a premature beat can encounter a zone of conduction block to initiate reentry. However, enhanced dispersion of repolarization, a necessary condition for initiation of reentry, is unlikely to be present in normal myocardium. Thus, the main objective of the present study was to perform detailed pace mapping measurements in normal ventricular myocardium with a view to identify pacing sites and critical coupling intervals which could induce spontaneous ectopic beats and to characterize the reentrant circuits.

Original languageEnglish
Article number2128
JournalJournal of Biological Research (Italy)
Volume87
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • Arrhythmia
  • Conduction block
  • Premature stimulation
  • Reentry circuit

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry, medical
  • Plant Science

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    Rossi, S., Baruffi, S., Callegari, S., Carnevali, L., Corradi, D., Miragoli, M., Musso, E., Sgoifo, A., Trombini, M., & Macchi, E. (2014). Can a single low-intensity premature stimulus induce ventricular arrhythmias in the normal heart? Journal of Biological Research (Italy), 87(1), [2128]. https://doi.org/10.4081/jbr.2014.2128