Can antihypertensive medication interfere with the vicious cycle between hypertension and vascular calcification?

Maria I. Pikilidou, Maria P. Yavropoulou, Angelo Scuteri

Research output: Contribution to journalArticlepeer-review

Abstract

Vascular calcification is a phenomenon of disturbed calcium deposition, as part of the calcium that is supposed to be deposited to our bones, is lodged to our vessels. There are two forms of vascular calcification, each with a distinct anatomical distribution and clinical relevance, namely the intimal and medial calcification. Studies have demonstrated that hypertension may cause vascular calcification but also that both types of calcification, especially medial, promote arterial rigidity and hence hypertension. Implications of this two-way road are largely unknown as there is no consensus yet on their exact clinical value. However, several antihypertensive medications seem to be able to interfere with the cycle of high blood pressure and vascular calcium deposits. The present review summarizes the up-to-date data regarding the effect of antihypertensive medication on vascular calcification.

Original languageEnglish
Pages (from-to)61-71
Number of pages11
JournalCardiovascular Drugs and Therapy
Volume28
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • Angiotensin converting enzyme inhibitors
  • Angiotensin receptor blockers
  • Antihypertensive medication
  • Calcium channel blockers
  • Vascular calcification

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Cardiology and Cardiovascular Medicine
  • Pharmacology

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