Can clinical data help to screen patients with lymphoma for MR imaging of bone marrow?

A. A. Tardivon, J. N. Munck, L. G. Shapeero, S. Koscielny, J. Bosq, F. Dhermain, R. Gilles, M. Hayat, D. Vanel

Research output: Contribution to journalArticle

Abstract

Background: Previous studies have suggested combining magnetic resonance (MR) imaging and biopsy in patients with lymphoma but associations between MR results and clinical symptoms have never been investigated. The purpose of this retrospective study was to better delineate patients profiles requiring bone marrow (BM) imaging in lymphoma. Material and methods: 50 MR studies and blind biopsies (BB) were reviewed in 40 patients with lymphoma. MR results were compared to clinical, laboratory-based and BM follow-up data to determine potential associations between MR results and these parameters. Results: 46% of MR studies were abnormal with a normal BB; 2% were normal with an abnormal BB. Abnormal MR results were significantly associated with subsequent bone marrow involvement (p <0.01). Abnormal MR studies were significantly associated with constitutional symptoms, bone pains (p <0.05) and an elevated alkaline phosphatase level (p <0.01). MR imaging excluded malignancy in three patients and caused therapy to be modified in three. Conclusion: Abnormal clinical and laboratory-based data should be used to screen patients with normal BB for MR imaging, especially in patients with Hodgkin's disease and high grade non-Hodgkin's lymphoma.

Original languageEnglish
Pages (from-to)795-800
Number of pages6
JournalAnnals of Oncology
Volume6
Issue number8
Publication statusPublished - 1995

Keywords

  • biopsy
  • bone marrow
  • comparative studies
  • lymphoma
  • magnetic resonance studies

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Public Health, Environmental and Occupational Health
  • Neuropsychology and Physiological Psychology
  • Hematology

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  • Cite this

    Tardivon, A. A., Munck, J. N., Shapeero, L. G., Koscielny, S., Bosq, J., Dhermain, F., Gilles, R., Hayat, M., & Vanel, D. (1995). Can clinical data help to screen patients with lymphoma for MR imaging of bone marrow? Annals of Oncology, 6(8), 795-800.