Can GH induce chromosome breaks or microsatellite instability in GH-deficient children?

C. Olivieri, C. Danesino, S. Scappaticci, Mauro Bozzola

Research output: Contribution to journalArticlepeer-review

Abstract

The role of GH in carcinogenesis is unclear. We studied the effect of recombinant human GH (rhGH) in vitro on chromosomal and genomic instability. Thirteen children, aged 9.57±1.08 yr (mean± SEM), with complete (no.=5) or partial (no.=8) GH deficiency were evaluated before and during GH treatment. We examined the incidence of chromosome and chromatid breaks, and microsatellite instability after in vitro addition of two different doses of rhGH to peripheral blood lymphocytes obtained from the patients. No differences were observed between the samples of GH-deficient children before and after GH therapy as regards the percentage of chromosome and chromatids breaks, and in microsatellite instability. Our data show that in vitro addition of rhGH does not induce chromosomal and/or genomic instability in cultured lymphocytes.

Original languageEnglish
Pages (from-to)308-310
Number of pages3
JournalJournal of Endocrinological Investigation
Volume27
Issue number4
Publication statusPublished - Apr 2004

Keywords

  • Cancer
  • Chromosome breaks
  • GH
  • GH-deficient children
  • Microsatellite instability

ASJC Scopus subject areas

  • Endocrinology

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