Can hepatocellular cancer screening increase the proportion of long-term survivors?

Christopher J. Gannon, Francesco Izzo, Thomas A. Aloia, Sandro Pignata, Guglielmo Nasti, Paolo Vallone, Raffaele Orlando, Fabrizio Scordino, Steven A. Curley

Research output: Contribution to journalArticle

Abstract

Background/Aims: Historically, only 10% of hepatocellular cancer (HCC) patients are diagnosed with early stage, potentially curable disease. We prospectively screened chronic hepatitis virus-infected patients to determine 1) the proportion diagnosed with potentially curable HCC, and 2) survival following curative therapy. Methodology: The study included 5670 chronic hepatitis B (1,077, 19.0%), C (4,196, 74.0%), or both (397, 7.0%)-infected patients enrolled in a prospective screening program. Screening was every 6 months with serum alpha-fetoprotein (AFP) measurement and ultrasonography. Curative treatments included liver transplantation, resection, RFA, and/or ethanol injection. Results: HCC was diagnosed in 464 (8.2%) patients. Of 1006 cirrhotic patients, 462 (45.9%) developed HCC. Curative treatment was possible in 319 (68.7%). The 2- and 5-year overall survival rates in the curative treatment group were 65% and 28%, respectively, compared to 10% and 0% in the advanced disease group (p

Original languageEnglish
Pages (from-to)1152-1156
Number of pages5
JournalHepato-Gastroenterology
Volume56
Issue number93
Publication statusPublished - Jul 2009

Keywords

  • Cirrhosis
  • Curative
  • Hepatitis
  • Radiofrequency ablation
  • Resection

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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  • Cite this

    Gannon, C. J., Izzo, F., Aloia, T. A., Pignata, S., Nasti, G., Vallone, P., Orlando, R., Scordino, F., & Curley, S. A. (2009). Can hepatocellular cancer screening increase the proportion of long-term survivors? Hepato-Gastroenterology, 56(93), 1152-1156.