Can hepatocellular carcinoma (HCC) produce unconventional metastases? Four cases of extrahepatic HCC

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9 Citations (Scopus)

Abstract

Aims and background. Extrahepatic spread of hepatocellular carcinoma (HCC) diagnosed during the clinical course of the disease is not frequent; however, with the prolonged survival of HCC patients, the incidence of extrahepatic metastases seems to be increasing. Methods and study design.We present four unusual cases of extrahepatic metastasis from HCC: the first concerns a patient who underwent a liver transplantation for HCC with cirrhosis and three years later developed metastases in the lung and the left orbit; the second is that of a patient who developed an extraperitoneal pararectal metastasis; in the third case a large osteolytic lesion developed on the left iliac bone, and in the fourth case we found an isolated metastasis in the left mandible. Results and conclusions. These cases offer important information related to the unusual biology of isolated metastases from HCC after successful treatment of the primary cancer.

Original languageEnglish
JournalTumori
Volume99
Issue number1
DOIs
Publication statusPublished - Jan 2013

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Hepatocellular Carcinoma
Neoplasm Metastasis
Orbit
Mandible
Liver Transplantation
Fibrosis
Bone and Bones
Lung
Survival
Incidence
Neoplasms
Therapeutics

Keywords

  • Extrahepatic metastases
  • Hepatocellular carcinoma
  • Histopathology

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

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title = "Can hepatocellular carcinoma (HCC) produce unconventional metastases? Four cases of extrahepatic HCC",
abstract = "Aims and background. Extrahepatic spread of hepatocellular carcinoma (HCC) diagnosed during the clinical course of the disease is not frequent; however, with the prolonged survival of HCC patients, the incidence of extrahepatic metastases seems to be increasing. Methods and study design.We present four unusual cases of extrahepatic metastasis from HCC: the first concerns a patient who underwent a liver transplantation for HCC with cirrhosis and three years later developed metastases in the lung and the left orbit; the second is that of a patient who developed an extraperitoneal pararectal metastasis; in the third case a large osteolytic lesion developed on the left iliac bone, and in the fourth case we found an isolated metastasis in the left mandible. Results and conclusions. These cases offer important information related to the unusual biology of isolated metastases from HCC after successful treatment of the primary cancer.",
keywords = "Extrahepatic metastases, Hepatocellular carcinoma, Histopathology",
author = "Mauro Piccirillo and Vincenza Granata and Vittorio Albino and Raffaele Palaia and Setola, {Sergio Venanzio} and Antonella Petrillo and Fabiana Tatangelo and Gerardo Botti and Margherita Foggia and Francesco Izzo",
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T1 - Can hepatocellular carcinoma (HCC) produce unconventional metastases? Four cases of extrahepatic HCC

AU - Piccirillo, Mauro

AU - Granata, Vincenza

AU - Albino, Vittorio

AU - Palaia, Raffaele

AU - Setola, Sergio Venanzio

AU - Petrillo, Antonella

AU - Tatangelo, Fabiana

AU - Botti, Gerardo

AU - Foggia, Margherita

AU - Izzo, Francesco

PY - 2013/1

Y1 - 2013/1

N2 - Aims and background. Extrahepatic spread of hepatocellular carcinoma (HCC) diagnosed during the clinical course of the disease is not frequent; however, with the prolonged survival of HCC patients, the incidence of extrahepatic metastases seems to be increasing. Methods and study design.We present four unusual cases of extrahepatic metastasis from HCC: the first concerns a patient who underwent a liver transplantation for HCC with cirrhosis and three years later developed metastases in the lung and the left orbit; the second is that of a patient who developed an extraperitoneal pararectal metastasis; in the third case a large osteolytic lesion developed on the left iliac bone, and in the fourth case we found an isolated metastasis in the left mandible. Results and conclusions. These cases offer important information related to the unusual biology of isolated metastases from HCC after successful treatment of the primary cancer.

AB - Aims and background. Extrahepatic spread of hepatocellular carcinoma (HCC) diagnosed during the clinical course of the disease is not frequent; however, with the prolonged survival of HCC patients, the incidence of extrahepatic metastases seems to be increasing. Methods and study design.We present four unusual cases of extrahepatic metastasis from HCC: the first concerns a patient who underwent a liver transplantation for HCC with cirrhosis and three years later developed metastases in the lung and the left orbit; the second is that of a patient who developed an extraperitoneal pararectal metastasis; in the third case a large osteolytic lesion developed on the left iliac bone, and in the fourth case we found an isolated metastasis in the left mandible. Results and conclusions. These cases offer important information related to the unusual biology of isolated metastases from HCC after successful treatment of the primary cancer.

KW - Extrahepatic metastases

KW - Hepatocellular carcinoma

KW - Histopathology

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