Can high-resolution ultrasound avoid the sentinel lymph-node biopsy procedure in the staging process of patients with stage I-II cutaneous melanoma?

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: The objective of our study was to define the diagnostic accuracy of high-resolution ultrasound (US) in detecting nodal involvement before sentinel lymph node biopsy (SLNB) in patients with cutaneous melanoma, to define the sonographic criteria used to assess nodal metastases, and to establish if high-resolution US can directly select patients to radical lymphadenectomy, sparing selective lymphadenectomy. Materials and Methods: 623 patients underwent high-resolution US of the regional lymph nodes, 24 hours prior being submitted to the sentinel lymph node biopsy procedure. The US findings were compared with histological findings. Results: In 14.7% out of 122 excised lymph nodes, high-resolution US showed sonographic features consistent with malignant involvement before the surgical step.US scan sensitivity and specificity were 15 and 100%, respectively, since positive and negative predictive values were 100 and 87% respectively. Conclusion: US is an effective modality in the presurgical detection of subclinical deposits within sentinel lymph nodes. However, preoperative staging work-up with high-resolution US cannot substitute the SLNB, mainly because of low sensitivity due to missing many micrometastases.

Original languageEnglish
JournalUltraschall in der Medizin
Volume33
Issue number7
DOIs
Publication statusPublished - 2012

Fingerprint

Sentinel Lymph Node Biopsy
Melanoma
Lymph Node Excision
Skin
Lymph Nodes
Neoplasm Micrometastasis
Neoplasm Metastasis
Sensitivity and Specificity

Keywords

  • lymphatic
  • skin
  • soft tissues
  • tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

@article{07332e6601ac42808aacb7753b705b93,
title = "Can high-resolution ultrasound avoid the sentinel lymph-node biopsy procedure in the staging process of patients with stage I-II cutaneous melanoma?",
abstract = "Purpose: The objective of our study was to define the diagnostic accuracy of high-resolution ultrasound (US) in detecting nodal involvement before sentinel lymph node biopsy (SLNB) in patients with cutaneous melanoma, to define the sonographic criteria used to assess nodal metastases, and to establish if high-resolution US can directly select patients to radical lymphadenectomy, sparing selective lymphadenectomy. Materials and Methods: 623 patients underwent high-resolution US of the regional lymph nodes, 24 hours prior being submitted to the sentinel lymph node biopsy procedure. The US findings were compared with histological findings. Results: In 14.7{\%} out of 122 excised lymph nodes, high-resolution US showed sonographic features consistent with malignant involvement before the surgical step.US scan sensitivity and specificity were 15 and 100{\%}, respectively, since positive and negative predictive values were 100 and 87{\%} respectively. Conclusion: US is an effective modality in the presurgical detection of subclinical deposits within sentinel lymph nodes. However, preoperative staging work-up with high-resolution US cannot substitute the SLNB, mainly because of low sensitivity due to missing many micrometastases.",
keywords = "lymphatic, skin, soft tissues, tumor",
author = "U. Marone and O. Catalano and C. Carac{\`o} and Anniciello, {A. M.} and F. Sandomenico and {Di Monta}, G. and {Di Cecilia}, {M. L.} and S. Mori and G. Botti and A. Petrillo and N. Mozzillo",
year = "2012",
doi = "10.1055/s-0032-1312827",
language = "English",
volume = "33",
journal = "Ultraschall in der Medizin",
issn = "0172-4614",
publisher = "Georg Thieme Verlag",
number = "7",

}

TY - JOUR

T1 - Can high-resolution ultrasound avoid the sentinel lymph-node biopsy procedure in the staging process of patients with stage I-II cutaneous melanoma?

AU - Marone, U.

AU - Catalano, O.

AU - Caracò, C.

AU - Anniciello, A. M.

AU - Sandomenico, F.

AU - Di Monta, G.

AU - Di Cecilia, M. L.

AU - Mori, S.

AU - Botti, G.

AU - Petrillo, A.

AU - Mozzillo, N.

PY - 2012

Y1 - 2012

N2 - Purpose: The objective of our study was to define the diagnostic accuracy of high-resolution ultrasound (US) in detecting nodal involvement before sentinel lymph node biopsy (SLNB) in patients with cutaneous melanoma, to define the sonographic criteria used to assess nodal metastases, and to establish if high-resolution US can directly select patients to radical lymphadenectomy, sparing selective lymphadenectomy. Materials and Methods: 623 patients underwent high-resolution US of the regional lymph nodes, 24 hours prior being submitted to the sentinel lymph node biopsy procedure. The US findings were compared with histological findings. Results: In 14.7% out of 122 excised lymph nodes, high-resolution US showed sonographic features consistent with malignant involvement before the surgical step.US scan sensitivity and specificity were 15 and 100%, respectively, since positive and negative predictive values were 100 and 87% respectively. Conclusion: US is an effective modality in the presurgical detection of subclinical deposits within sentinel lymph nodes. However, preoperative staging work-up with high-resolution US cannot substitute the SLNB, mainly because of low sensitivity due to missing many micrometastases.

AB - Purpose: The objective of our study was to define the diagnostic accuracy of high-resolution ultrasound (US) in detecting nodal involvement before sentinel lymph node biopsy (SLNB) in patients with cutaneous melanoma, to define the sonographic criteria used to assess nodal metastases, and to establish if high-resolution US can directly select patients to radical lymphadenectomy, sparing selective lymphadenectomy. Materials and Methods: 623 patients underwent high-resolution US of the regional lymph nodes, 24 hours prior being submitted to the sentinel lymph node biopsy procedure. The US findings were compared with histological findings. Results: In 14.7% out of 122 excised lymph nodes, high-resolution US showed sonographic features consistent with malignant involvement before the surgical step.US scan sensitivity and specificity were 15 and 100%, respectively, since positive and negative predictive values were 100 and 87% respectively. Conclusion: US is an effective modality in the presurgical detection of subclinical deposits within sentinel lymph nodes. However, preoperative staging work-up with high-resolution US cannot substitute the SLNB, mainly because of low sensitivity due to missing many micrometastases.

KW - lymphatic

KW - skin

KW - soft tissues

KW - tumor

UR - http://www.scopus.com/inward/record.url?scp=84871659702&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871659702&partnerID=8YFLogxK

U2 - 10.1055/s-0032-1312827

DO - 10.1055/s-0032-1312827

M3 - Article

VL - 33

JO - Ultraschall in der Medizin

JF - Ultraschall in der Medizin

SN - 0172-4614

IS - 7

ER -