Can infants be protected by means of maternal vaccination?

S. Esposito, S. Bosis, L. Morlacchi, E. Baggi, C. Sabatini, N. Principi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The administration of vaccines is not usually recommended in pregnant women because of a fear of severe adverse events for the fetus. However, contraindication to vaccination applies only to vaccines based on live attenuated viruses for the theoretical possibility that they might infect the fetus. In contrast, the use of several inactivated vaccines is useful and recommended. As a result of the transplacental passage of antibodies, maternal immunization can reduce the risk of vaccine-preventable diseases that may occur in the first months of life before the start or completion of the suggested vaccination schedule. One of the best examples is vaccination against influenza that can protect pregnant women from a disease that can lead to hospitalization and death in a significantly higher number of cases than in the general population and can induce protective specific antibody levels as well as being effective in infants in the first months of life. Other examples are vaccinations against tetanus, pertussis, pneumococcal infections and Haemophilus influenzae type b infection. This review analyses the advantages and limitations of maternal immunization as revealed by experience and the main publications.

Original languageEnglish
Pages (from-to)85-92
Number of pages8
JournalClinical Microbiology and Infection
Volume18
Issue numberSUPPL. 5
DOIs
Publication statusPublished - Oct 2012

Fingerprint

Vaccination
Mothers
Vaccines
Pregnant Women
Immunization
Fetus
Pneumococcal Infections
Haemophilus influenzae type b
Inactivated Vaccines
Antibodies
Whooping Cough
Tetanus
Human Influenza
Fear
Publications
Appointments and Schedules
Hospitalization
Viruses
Infection
Population

Keywords

  • Infant protection
  • Maternal immunization
  • Pregnancy
  • Prevention
  • Vaccination

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Can infants be protected by means of maternal vaccination? / Esposito, S.; Bosis, S.; Morlacchi, L.; Baggi, E.; Sabatini, C.; Principi, N.

In: Clinical Microbiology and Infection, Vol. 18, No. SUPPL. 5, 10.2012, p. 85-92.

Research output: Contribution to journalArticle

Esposito, S, Bosis, S, Morlacchi, L, Baggi, E, Sabatini, C & Principi, N 2012, 'Can infants be protected by means of maternal vaccination?', Clinical Microbiology and Infection, vol. 18, no. SUPPL. 5, pp. 85-92. https://doi.org/10.1111/j.1469-0691.2012.03936.x
Esposito, S. ; Bosis, S. ; Morlacchi, L. ; Baggi, E. ; Sabatini, C. ; Principi, N. / Can infants be protected by means of maternal vaccination?. In: Clinical Microbiology and Infection. 2012 ; Vol. 18, No. SUPPL. 5. pp. 85-92.
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