Can Osteoblastoma evolve to malignancy? A challenge in the decision-making process of a benign spine tumor

Addisu Mesfin; Stefano Boriani; Marco Gambarotti; Stefano Bandiera; Alessandro Gasbarrini

doi:10.1016/j.wneu.2019.11.148

Can Osteoblastoma evolve to malignancy? A challenge in the decision-making process of a benign spine tumor

Addisu Mesfin, Stefano Boriani, Marco Gambarotti, Stefano Bandiera, Alessandro Gasbarrini

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Osteoblastoma is a rare benign aggressive tumor; one third occurring in the spine. The conversion of osteoblastoma to osteosarcoma is uncommon and histologically proven conversion has been rarely reported. The objective of this study is to describe the rare occurrences of spinal osteoblastoma converting to osteosarcoma as well as to provide a literature review.

METHODS: The study design is a case report. Two patients with spinal osteoblastomas recurring and transforming into osteosarcomas are described. The initial presentation, treatment, imaging and histology findings are described.

RESULTS: The outcomes following surgical intervention for histologically diagnosed osteoblastoma with subsequent transformation to osteosarcoma and relative management are described. A literature review of the topic of osteoblastoma converting to osteosarcoma is provided.

CONCLUSION: The rare occurrence of osteoblastoma converting to osteosarcoma imparts several lessons including performing Enneking appropriate surgery for benign aggressive tumors (Enneking 3) as well always performing a biopsy, particularly at the recurrence if imaging is not pathognomonic for a benign primary spine tumor.

Original language	English
Pages (from-to)	150-156
Number of pages	7
Journal	World Neurosurg.
Volume	136
DOIs	https://doi.org/10.1016/j.wneu.2019.11.148
Publication status	E-pub ahead of print - Dec 3 2019

Keywords

En bloc resection
Enneking appropriate resection
malignancy
osteoblastoma
osteosarcoma
primary spine tumor

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title = "Can Osteoblastoma evolve to malignancy? A challenge in the decision-making process of a benign spine tumor",

abstract = "BACKGROUND: Osteoblastoma is a rare benign aggressive tumor; one third occurring in the spine. The conversion of osteoblastoma to osteosarcoma is uncommon and histologically proven conversion has been rarely reported. The objective of this study is to describe the rare occurrences of spinal osteoblastoma converting to osteosarcoma as well as to provide a literature review.METHODS: The study design is a case report. Two patients with spinal osteoblastomas recurring and transforming into osteosarcomas are described. The initial presentation, treatment, imaging and histology findings are described.RESULTS: The outcomes following surgical intervention for histologically diagnosed osteoblastoma with subsequent transformation to osteosarcoma and relative management are described. A literature review of the topic of osteoblastoma converting to osteosarcoma is provided.CONCLUSION: The rare occurrence of osteoblastoma converting to osteosarcoma imparts several lessons including performing Enneking appropriate surgery for benign aggressive tumors (Enneking 3) as well always performing a biopsy, particularly at the recurrence if imaging is not pathognomonic for a benign primary spine tumor.",

keywords = "En bloc resection, Enneking appropriate resection, malignancy, osteoblastoma, osteosarcoma, primary spine tumor",

author = "Addisu Mesfin and Stefano Boriani and Marco Gambarotti and Stefano Bandiera and Alessandro Gasbarrini",

year = "2019",

month = dec,

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doi = "10.1016/j.wneu.2019.11.148",

language = "English",

volume = "136",

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journal = "World Neurosurg.",

issn = "1878-8750",

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T1 - Can Osteoblastoma evolve to malignancy? A challenge in the decision-making process of a benign spine tumor

AU - Mesfin, Addisu

AU - Boriani, Stefano

AU - Gambarotti, Marco

AU - Bandiera, Stefano

AU - Gasbarrini, Alessandro

PY - 2019/12/3

Y1 - 2019/12/3

N2 - BACKGROUND: Osteoblastoma is a rare benign aggressive tumor; one third occurring in the spine. The conversion of osteoblastoma to osteosarcoma is uncommon and histologically proven conversion has been rarely reported. The objective of this study is to describe the rare occurrences of spinal osteoblastoma converting to osteosarcoma as well as to provide a literature review.METHODS: The study design is a case report. Two patients with spinal osteoblastomas recurring and transforming into osteosarcomas are described. The initial presentation, treatment, imaging and histology findings are described.RESULTS: The outcomes following surgical intervention for histologically diagnosed osteoblastoma with subsequent transformation to osteosarcoma and relative management are described. A literature review of the topic of osteoblastoma converting to osteosarcoma is provided.CONCLUSION: The rare occurrence of osteoblastoma converting to osteosarcoma imparts several lessons including performing Enneking appropriate surgery for benign aggressive tumors (Enneking 3) as well always performing a biopsy, particularly at the recurrence if imaging is not pathognomonic for a benign primary spine tumor.

AB - BACKGROUND: Osteoblastoma is a rare benign aggressive tumor; one third occurring in the spine. The conversion of osteoblastoma to osteosarcoma is uncommon and histologically proven conversion has been rarely reported. The objective of this study is to describe the rare occurrences of spinal osteoblastoma converting to osteosarcoma as well as to provide a literature review.METHODS: The study design is a case report. Two patients with spinal osteoblastomas recurring and transforming into osteosarcomas are described. The initial presentation, treatment, imaging and histology findings are described.RESULTS: The outcomes following surgical intervention for histologically diagnosed osteoblastoma with subsequent transformation to osteosarcoma and relative management are described. A literature review of the topic of osteoblastoma converting to osteosarcoma is provided.CONCLUSION: The rare occurrence of osteoblastoma converting to osteosarcoma imparts several lessons including performing Enneking appropriate surgery for benign aggressive tumors (Enneking 3) as well always performing a biopsy, particularly at the recurrence if imaging is not pathognomonic for a benign primary spine tumor.

KW - En bloc resection

KW - Enneking appropriate resection

KW - malignancy

KW - osteoblastoma

KW - osteosarcoma

KW - primary spine tumor

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DO - 10.1016/j.wneu.2019.11.148

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VL - 136

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JO - World Neurosurg.

JF - World Neurosurg.

SN - 1878-8750

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