TY - JOUR
T1 - Can the co-dependence of the immune system and angiogenesis facilitate pharmacological targeting of tumours?
AU - Mortara, Lorenzo
AU - Benest, Andrew V.
AU - Bates, David O.
AU - Noonan, Douglas M.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Tumours elicit a number of mechanisms to induce a reprogramming of innate and adaptive immune cells to their advantage, inducing a pro-angiogenic phenotype. Investigation of these events is now leading to the identification of specific myeloid and lymphoid cell-targeted therapies, as well as of unexplored off-target activities of clinically relevant chemotherapeutic and metabolic drugs. It is also leading to an enhanced understanding of the interplay between angiogenesis and the immune system, and the value of novel co-targeting approaches using both immunotherapy and anti-angiogenic therapy. Here, we review recently identified mechanisms and potential pharmacological approaches targeting the crosstalk between cancer cells and the host immune system, providing an overview on novel therapeutic opportunities linking immuno-oncology and anti-angiogenic therapy.
AB - Tumours elicit a number of mechanisms to induce a reprogramming of innate and adaptive immune cells to their advantage, inducing a pro-angiogenic phenotype. Investigation of these events is now leading to the identification of specific myeloid and lymphoid cell-targeted therapies, as well as of unexplored off-target activities of clinically relevant chemotherapeutic and metabolic drugs. It is also leading to an enhanced understanding of the interplay between angiogenesis and the immune system, and the value of novel co-targeting approaches using both immunotherapy and anti-angiogenic therapy. Here, we review recently identified mechanisms and potential pharmacological approaches targeting the crosstalk between cancer cells and the host immune system, providing an overview on novel therapeutic opportunities linking immuno-oncology and anti-angiogenic therapy.
UR - http://www.scopus.com/inward/record.url?scp=85020779791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020779791&partnerID=8YFLogxK
U2 - 10.1016/j.coph.2017.05.009
DO - 10.1016/j.coph.2017.05.009
M3 - Review article
AN - SCOPUS:85020779791
VL - 35
SP - 66
EP - 74
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
SN - 1471-4892
ER -