Can the co-dependence of the immune system and angiogenesis facilitate pharmacological targeting of tumours?

Lorenzo Mortara, Andrew V. Benest, David O. Bates, Douglas M. Noonan

Research output: Contribution to journalReview article

Abstract

Tumours elicit a number of mechanisms to induce a reprogramming of innate and adaptive immune cells to their advantage, inducing a pro-angiogenic phenotype. Investigation of these events is now leading to the identification of specific myeloid and lymphoid cell-targeted therapies, as well as of unexplored off-target activities of clinically relevant chemotherapeutic and metabolic drugs. It is also leading to an enhanced understanding of the interplay between angiogenesis and the immune system, and the value of novel co-targeting approaches using both immunotherapy and anti-angiogenic therapy. Here, we review recently identified mechanisms and potential pharmacological approaches targeting the crosstalk between cancer cells and the host immune system, providing an overview on novel therapeutic opportunities linking immuno-oncology and anti-angiogenic therapy.

Original languageEnglish
Pages (from-to)66-74
Number of pages9
JournalCurrent Opinion in Pharmacology
Volume35
DOIs
Publication statusPublished - Aug 1 2017

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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