Can the pattern of neuropsychological improvement obtained with cholinergic drugs be used to infer a cholinergic mechanism in other nootropic drugs?

Guido Gainottin, Ugo Nocentini, Elio Sena

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Gainotti, Guido, Nocentini, Ugo and Sena, Elio: Can the Pattern of Neuropsychological Improvement Obtained with Cholinergic Drugs Be Used to Infer a Cholinergic Mechanism in Other Nootroplc Drugs? Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1989, 13 (Supple): S47-S59 1. 1. Enhancement of episodic memory and reduction of intrusion errors are considered as the most characteristic outcome of cholinergic drugs administration in AD patients. 2. 2. Since the nootroplc drugs Piracetam and Oxiracetam are deemed to act through a cholinergic mechanism, we checked whether AD patients treated with these drugs would show the same pattern of neuropsychological improvement. 3. 3. Results were negative, since (a) episodic memory showed a similar degree of improvement both in patients treated with these drugs and in patients treated with placebo; (b) the number of intrusions tended to increase, rather than to decrease, after the treatment period.

Original languageEnglish
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume13
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 1989

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Nootropic Agents
Cholinergic Agents
Episodic Memory
Pharmaceutical Preparations
Piracetam
Placebos

Keywords

  • acetylcholine
  • Alzheimer disease
  • cholinergic drugs
  • neuropsychological evaluation
  • nootroplc drugs

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

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abstract = "Gainotti, Guido, Nocentini, Ugo and Sena, Elio: Can the Pattern of Neuropsychological Improvement Obtained with Cholinergic Drugs Be Used to Infer a Cholinergic Mechanism in Other Nootroplc Drugs? Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1989, 13 (Supple): S47-S59 1. 1. Enhancement of episodic memory and reduction of intrusion errors are considered as the most characteristic outcome of cholinergic drugs administration in AD patients. 2. 2. Since the nootroplc drugs Piracetam and Oxiracetam are deemed to act through a cholinergic mechanism, we checked whether AD patients treated with these drugs would show the same pattern of neuropsychological improvement. 3. 3. Results were negative, since (a) episodic memory showed a similar degree of improvement both in patients treated with these drugs and in patients treated with placebo; (b) the number of intrusions tended to increase, rather than to decrease, after the treatment period.",
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